Zhouzhi Qingqingbao Pharmaceutical Co., Ltd.

This product belongs to the vitamin P family and is a glycoside of dehydroflavonoids. It often coexists with vitamin C in food. Vitamin P is a hydrogen carrier and may participate in the action of oxidoreductase in the body, which can affect the activity of the thyroid gland and prevent adrenaline from oxidation. In the body, it can enhance the action of vitamin C and promote its accumulation in the body. When it is deficient in the body, the fragility of capillaries increases. Its main pharmacological action is to maintain vascular elasticity, enhance capillary resistance, reduce its fragility and permeability, and promote its cell proliferation and prevent blood cell aggregation. It also has anti-inflammatory and anti-allergic effects.

1. Anti-inflammatory effect: (1) Anti-allergic effect. Glycyrrhizin can inhibit the local allergic necrosis reaction and Schwartzman phenomenon in rabbits. (2) Inhibitory effect on arachidonic acid metabolic enzymes, selectively inhibiting the phosphorylation of phospholipase A2 and lipoxygenase and inhibiting their activation. 2. Immunomodulatory effect: (1) Regulatory effect on T cell activation; (2) Inducing effect on g interferon; (3) Activating NK cells; (4) Promoting the differentiation of extrathymic T lymphocytes. 3. Inhibitory effect on experimental hepatocyte damage: In vitro experiments inhibited hepatocyte damage caused by carbon tetrachloride. 4. Inhibitory effect on virus proliferation and inactivation: Prolong the survival days of mice infected with MHV, prevent the occurrence of vaccinia virus in rabbits, and in vitro inhibition of the proliferation of herpes virus and inactivation of viruses were observed.

The antiasthmatic effect is slightly weaker than that of theophylline, and the cardiac stimulant effect is only 1/20~1/10 of that of aminophylline. It has less effect on the heart and nervous system, and is especially suitable for asthma patients with tachycardia. It has a direct relaxant effect on respiratory smooth muscle, and its mechanism of action is the same as that of theophylline. It may increase the intracellular cAMP content by inhibiting phosphodiesterase, or achieve bronchial dilation by releasing endogenous adrenaline and norepinephrine. At the same time, theophylline, as a purine receptor blocker, can counteract the contractile effect of adenine on the respiratory tract, and can enhance the contractility of the diaphragm to improve respiratory function.