Metoprolol Tartrate Tablets
Function and Efficacy
This drug belongs to Class 2A, i.e., a β1-receptor blocker without partial agonist activity (cardioselective β-receptor blocker). It has a selective blocking effect on β1-receptors, no PAA (partial agonist activity), and no membrane stabilizing effect. Its effect on blocking β-receptors is approximately equal to that of propranolol (PP), and its selectivity for β1-receptors is slightly inferior to that of atenolol. Metoprolol's effects on the heart, such as slowing heart rate, inhibiting cardiac contractility, reducing automaticity, and delaying atrioventricular conduction time, are similar to those of propranolol and atenolol (AT). Its effect on reducing elevated blood pressure and heart rate during exercise testing is also similar to that of PP and AT. Its contraction effect on vascular and bronchial smooth muscle is weaker than that of PP, so its effect on the respiratory tract is also smaller, but still stronger than that of AT. Metoprolol can also reduce plasma renin activity.
Ingredients
The main ingredient and its chemical name are: 1-isopropylamino-3-[p-(2-methoxyethyl)phenoxy]-2-propanol L()-tartrate. Its structural formula is: Molecular formula: (C15H25NO3)2C4H6O6 Molecular weight: 684.82
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Metoprolol tartrateIngredients |
This drug belongs to Class 2A, i.e., a β1-receptor blocker without partial agonist activity (cardioselective β-receptor blocker). It has a selective blocking effect on β1-receptors, no PAA (partial agonist activity), and no membrane stabilizing effect. Its effect on blocking β-receptors is approximately equal to that of propranolol (PP), and its selectivity for β1-receptors is slightly inferior to that of atenolol. Metoprolol's effects on the heart, such as slowing heart rate, inhibiting cardiac contractility, reducing automaticity, and delaying atrioventricular conduction time, are similar to those of propranolol and atenolol (AT). Its effect on reducing elevated blood pressure and heart rate during exercise testing is also similar to that of PP and AT. Its contraction effect on vascular and bronchial smooth muscle is weaker than that of PP, so its effect on the respiratory tract is also smaller, but still stronger than that of AT. Metoprolol can also reduce plasma renin activity. More |
56392-17-7 | 49 |
Appearance
This product is white tablets.
Indication
It is used to treat hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, arrhythmia, hyperthyroidism, cardiac neurosis, etc. In recent years, it is also used to treat heart failure, and it should be used under the guidance of an experienced physician.
Usage and Dosage
For the treatment of hypertension, 100-200 mg/time, twice a day, should be used immediately after hemodynamic stabilization. Acute myocardial infarction advocates early use, i.e., within the first few hours, because immediate use can reduce the infarction range and reduce the short-term (15-day) mortality rate in patients who have not undergone thrombolysis (this effect appears 24 hours after medication). It can reduce the reinfarction rate and re-ischemia rate in patients who have undergone thrombolysis, and can also reduce the mortality rate if the medication is used within 2 hours. General usage: Metoprolol can be injected intravenously at 2.5-5 mg/time (within 2 minutes), once every 5 minutes, for a total of 3 times of 10-15 mg. After 15 minutes, start taking 25-50 mg orally, once every 6-12 hours, for a total of 24-48 hours, and then take 50-100 mg orally, twice a day.
Adverse Reactions
1 Cardiovascular system: slow heart rate, conduction block, lowered blood pressure, worsening heart failure, cold limbs or untouchable pulse due to peripheral vascular spasm, Raynaud's phenomenon, 2 Because of its fat solubility and easy penetration into the central nervous system, this system has more adverse reactions. Fatigue and dizziness account for 10%, depression accounts for 5%, and others include headache, dreaminess, insomnia, etc. Occasionally, hallucinations are seen. 3 Digestive system: nausea, stomachache, constipation 1%, diarrhea accounts for 5%, but it is not serious and rarely affects medication. 4 Others: shortness of breath, joint pain, itching, retroperitoneal fibrosis, deafness, eye pain, etc.
Precautions
Hypotension, significant bradycardia (heart rate 45/minute), cardiogenic shock, severe or acute heart failure, poor peripheral circulation perfusion, second-degree or third-degree atrioventricular block, sick sinus syndrome, severe peripheral vascular disease.
Special Population Medication
Precautions for children: There is limited experience with the use of this product in children. Precautions for pregnancy and lactation: The use of beta-blockers during pregnancy can cause various problems for the fetus, including fetal growth retardation. Beta-blockers can have adverse effects on the fetus and newborn, especially bradycardia, so they should not be used during pregnancy or delivery. Precautions for the elderly: The pharmacokinetics of the elderly are not significantly different from those of young people, so the dosage does not need to be adjusted for elderly patients.
Drug Interactions
Combination with cimetidine or prior use of quinidine can increase the plasma concentration of metoprolol; combination with reserpine can enhance the effect of this product, but attention should be paid to hypotension and tachycardia.
Storage
Keep away from light and store in sealed container.
Packaging Specification
50mg
Validity Period
36 months
Manufacturer
Suzhou Amerigen Pharmaceutical Co., Ltd.
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Founded in:
1997-06-03 -
Address:
No. 58, Qunxing 1st Road, Suzhou Industrial Park -
Tax NO.:
913205946082070779 -
Registered Funds:
129.92963402 yuan -
Website:
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Email: