Sodium Nitroprusside for Injection

This product is a powerful vasodilator that can directly relax the smooth muscle of arterioles and veins, lower blood pressure, reduce the preload and afterload of the heart, thereby reducing the myocardial load, reducing myocardial oxygen consumption, and increasing the blood output of the failing left ventricle. It can also significantly reduce pulmonary artery pressure, and there is no significant change in renal blood flow and glomerular filtration rate. This product acts quickly and lasts for a short time. It is generally intravenously dripped, and the drip rate and dosage are adjusted to control blood pressure at a certain level.

Sodium nitroprusside. Chemical name: Sodium nitrosoferricyanide dihydrate.

This product is pink crystalline powder. The aqueous solution is unstable when placed on ice and decomposes rapidly under light.

1. Used for emergency hypotension in hypertensive emergencies, such as hypertensive crisis, hypertensive encephalopathy, malignant hypertension, paroxysmal hypertension before and after pheochromocytoma surgery, etc. It can also be used for controlled hypotension during surgical anesthesia. 2. Used for acute heart failure, including acute pulmonary edema. It is also used for acute heart failure with acute myocardial infarction or valvular (mitral or aortic) insufficiency.

Dilute with 5% glucose solution and protect from light. The method of administration is generally continuous intravenous drip, and the dosage is adjusted according to blood pressure monitoring. The general speed is 0.5-8 μg/minute per kilogram of body weight. For those who have received other antihypertensive drugs, the dose should be small, and the maximum dose can be 40 μg/minute per kilogram of body weight. For patients with heart failure, it can be started from 20-40 μg/minute per kilogram of body weight, intravenous drip for 8-12 hours a day, ensure that the patient rests at night, and monitor the blood thiocyanate concentration.

Nausea, vomiting, mental restlessness, muscle cramps, headache, rash, sweating, fever, etc. When used continuously in large doses, patients with liver and kidney damage may suffer from increased plasma cyanide and thiocyanate concentrations and poisoning. This product may cause hypothyroidism, methemoglobinemia, phlebitis and metabolic acidosis.

It is contraindicated for pregnant women and patients with compensated hypertension such as arteriovenous shunt or aortic stenosis.

Precautions during pregnancy and lactation: Contraindicated for use by pregnant women.

1. When used with other antihypertensive drugs, blood pressure can drop dramatically. 2. When used with dobutamine, cardiac output can be increased and pulmonary capillary pressure can be reduced. 3. When used with sympathomimetic amines, the antihypertensive effect of this product is weakened.

Keep away from light and store in sealed container.

50mg (equivalent to 43.96mg anhydrous)

Kaifeng Kangnuo Pharmaceutical Co., Ltd.

• Founded in:

  2003-09-26

• Address:

  No. 66, South Section of Jinming Avenue, Nanyuan Street, Gulou District, Kaifeng City, Henan Province

• Tax NO.:

  91410200753894686D

• Registered Funds:

  8.99 million yuan

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