Omeprazole enteric-coated capsules

Proton pump inhibitor. This product is a fat-soluble weakly alkaline drug that is easily concentrated in an acidic environment. Therefore, after oral administration, it can be specifically distributed in the secretory tubules of the gastric mucosal parietal cells, and converted into the active form of sulfenamide in this high-acid environment. Then it irreversibly combines with the residues of H, K-ATPase (also known as proton pump) in the secretory membrane of gastric cells through a sulfur bond to form a complex of sulfenamide and proton pump. Thereby inhibiting the activity of the enzyme and blocking the last step of gastric acid secretion. Therefore, this product has a strong and lasting inhibitory effect on gastric acid secretion caused by various reasons.

Each tablet of this product contains 10 mg of omeprazole, and the excipients are: starch, microcrystalline cellulose, anhydrous sodium carbonate, sodium carboxymethyl cellulose, sucrose, hydroxypropyl methylcellulose, 95% ethanol, talc, Tween-80, polyacrylic acid resin II, castor oil, diethyl phthalate, and titanium dioxide.

The content of this product is white or off-white enteric-coated granules or pellets

Indicated for peptic ulcer (stomach, duodenum), reflux esophagitis and Zollinger-Ellison syndrome (gastrinoma).

Oral administration, do not chew. 1. Peptic ulcer: 20 mg (1 tablet at a time), 1 to 2 times a day. Swallow in the morning or once in the morning and evening. The treatment course for gastric ulcer is usually 4 to 8 weeks, and the treatment course for duodenal ulcer is usually 2 to 4 weeks. 2. Reflux esophagitis: 20 to 60 mg (1 to 3 tablets at a time), 1 to 2 times a day. Swallow in the morning or once in the morning and evening. The treatment course is usually 4 to 8 weeks. 3. Zollinger-Ellison syndrome: 60 mg (3 tablets at a time), once a day. The total daily dose can be adjusted to 20 to 120 mg (1 to 6 tablets) according to the condition. If the total daily dose needs to exceed 80 mg (4 tablets), it should be taken in two doses.

1. Headache, diarrhea, nausea, vomiting, constipation, abdominal pain and bloating. Occasionally dizziness, drowsiness, fatigue, sleep disorders, paresthesia, rash, itching, urticaria, abnormal liver function tests, etc. Rarely, hyperhidrosis, peripheral angioedema, hyponatremia. 2. Angioedema, fever and anaphylactic shock. 3. Leukopenia, thrombocytopenia, agranulocytosis, pancytopenia. 4. Reversible mental confusion, irritability, depression, aggression and hallucinations. 5. Gynecomastia, dry mouth, taste abnormalities, stomatitis, candidiasis. 6. Hair loss, photosensitivity, erythema multiforme. 7. Hepatic encephalopathy, icteric or non-icteric hepatitis, liver failure. 8. Bronchospasm, arthralgia, myalgia, muscle fatigue, interstitial nephritis. 9. Blurred vision.

It is contraindicated for patients who are allergic to this product, have severe renal insufficiency and infants.

Precautions for children: It is forbidden to use in infants and young children. Precautions for pregnancy and lactation: Although this product has no teratogenic effect in animal experiments, it should generally not be used by pregnant women, and should also be used with caution by lactating women. Precautions for the elderly: It is not yet clear.

This product can delay the elimination of drugs metabolized by the liver in the body, such as diazepam, phenytoin sodium, warfarin, nifedipine, etc. When this product is used together with the above-mentioned drugs, the dosage of the latter should be reduced.

Light-proof and sealed.

20 mg

24 months.

AstraZeneca Pharmaceutical Co., Ltd.

• Founded in:

  1993-10-26

• Address:

  No. 2 Huangshan Road, New District, Wuxi

• Tax NO.:

  91320214607915071G

• Registered Funds:

  $191.2 million

• Email:

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