Isosorbide mononitrate extended-release tablets

This drug contains two active ingredients, namely isosorbide mononitrate and aspirin. Isosorbide mononitrate is the main active metabolite of isosorbide dinitrate. It can reduce myocardial oxygen consumption by dilating peripheral blood vessels, especially increasing venous blood volume, reducing venous return, and reducing cardiac preload and postload; it can also promote myocardial blood flow redistribution and improve blood supply to ischemic areas. Isosorbide mononitrate may play an anti-myocardial ischemic role through these two aspects. Aspirin acetylates platelet cyclooxygenase (i.e., prostaglandin synthase), thereby reducing the generation of thromboxane A2 (TXA2), producing an irreversible inhibitory effect on TXA2-induced platelet aggregation, and also inhibiting ADP or adrenaline-induced phase II aggregation; it can also inhibit platelet aggregation and release reactions and spontaneous aggregation caused by low concentrations of collagen, thrombin, antibody-antigen complexes, certain viruses and bacteria, thereby preventing the formation of thrombus. At high concentrations, aspirin can also inhibit PG synthase in the blood vessel wall and reduce the synthesis of prostacyclin (PGI2). PGI2 is a physiological antagonist of TXA2, and its reduced synthesis may promote the formation of blood clots.

Ingredients: Isosorbide mononitrate.

This product is a film-coated tablet. After removing the film coating, it becomes a white or off-white double-layer tablet.

Prevention of long-term treatment of angina pectoris. Treatment after myocardial infarction. In combination with digitalis glycosides and/or diuretics, it is used as an adjuvant therapy for severe myocardial insufficiency. Pulmonary hypertension.

Oral: Take 1 tablet every morning. For severe cases, take 2 tablets every morning. If headache occurs, the initial dose can be reduced to half a tablet per day. The whole tablet or half tablet should be kept intact before taking, swallowed with half a cup of water, and should not be chewed or crushed.

1 Side effects such as skin flushing (a manifestation of vasodilation) are generally mild. 2 Allergic reactions, fatigue, nausea, vomiting, etc. are occasionally seen, and generally disappear on their own after stopping the drug.

Patients with the following symptoms are contraindicated: 1. Allergy to the active ingredients of this product or similar drugs (non-steroidal anti-inflammatory drugs, NSAIDS); 2. Asthma; 3. Cerebral hemorrhage; 4. Bleeding and coagulation disorders; 5. Children under 16 years old; 6. Craniocerebral injury; 7. Heart attack caused by other cardiac reasons; 8. Hypotension; 9. Decreased blood volume; 10. Peptic ulcer; 11. Severe anemia; 12. Severe cerebrovascular insufficiency; 13. Acute myocardial infarction with decreased left ventricular filling pressure; 14. Evidence has shown that sildenafil can enhance the antihypertensive response of nitrates, so the combination of the two is contraindicated.

Precautions for children: Children under 16 years old; Precautions for pregnancy and lactation: Use with caution for pregnant and lactating women. Precautions for the elderly: Not yet clear.

Not yet clear.

Keep away from light and store in a sealed container.

60mg

Tentatively two years.

Nanjing Cuccess Pharmaceutical Co., Ltd.

• Founded in:

  2002-03-20

• Address:

  No. 20, Xingang Avenue, Nanjing Economic and Technological Development Zone

• Tax NO.:

  913201926089285606

• Registered Funds:

  60 million yuan

• Website:

  Log in to view

• Email:

  Log in to view