Hydrocortisone injection

Adrenal cortex hormone drugs. They have multiple pharmacological effects such as anti-inflammatory, anti-allergic and immunosuppressive. (1) Anti-inflammatory effect: Glucocorticoids reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation. (2) Immunosuppressive effect: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, and reduce the expansion of primary immune responses. (3) Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a protective role.

Hydrocortisone

This product is a colorless clear liquid.

It is used to rescue critically ill patients with toxic infections (tuberculous meningitis, pleurisy, arthritis, tenosynovitis, acute and chronic sprains, tendon strain), anaphylactic shock, severe adrenocortical insufficiency, connective tissue diseases, severe bronchial asthma and other allergic diseases, and can be used to prevent and treat acute transplant rejection.

Intravenous drip: 50-100 mg at a time, mixed with 500 ml of physiological sodium chloride injection or 5% glucose injection and then dripped. For the treatment of adult adrenal insufficiency and anterior pituitary insufficiency crisis, severe allergic reaction, asthmatic status, shock, each free form 100 mg or hydrocortisone sodium succinate 135 mg intravenous drip, can be used up to 300 mg per day, the course of treatment does not exceed 3-5 days.

There are no obvious adverse reactions when glucocorticoids are used for replacement therapy at physiological doses. Adverse reactions mostly occur when pharmacological doses are used, and are closely related to the course of treatment, dose, type of medication, usage and route of administration. Common adverse reactions are as follows: 1. Long-term use may cause the following side effects: iatrogenic Cushing's syndrome face and body shape, weight gain, lower limb edema, purple lines, bleeding tendency, poor wound healing, acne, menstrual disorders, avascular necrosis of the humeral or femoral head, osteoporosis and fractures (including vertebral compression fractures, long bone pathological fractures), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, growth inhibition in children, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and aggravation of diabetes. 2. Patients may experience mental symptoms: euphoria, agitation, delirium, restlessness, disorientation, and may also manifest as inhibition. Mental symptoms are more likely to occur in people with chronic wasting diseases and those who have had mental disorders in the past. 3. Concurrent infection is the main adverse reaction of adrenocortical hormones. Fungi, tuberculosis, staphylococcus, Proteus, Pseudomonas aeruginosa and various herpes viruses are the main ones. 4. Corticosteroid withdrawal syndrome. Sometimes patients experience dizziness, fainting tendency, abdominal pain or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, and weakness after stopping the drug. If careful examination can rule out adrenocortical insufficiency and recurrence of the original disease, it can be considered as a syndrome of dependence on glucocorticoids.

Patients who are allergic to this product and other steroid hormones are prohibited from using it. Patients with the following diseases should not use it in general. In special cases, the pros and cons should be weighed, but attention should be paid to the possibility of worsening of the condition: severe mental illness (past or present) and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fractures, wound repair period, corneal ulcer, hyperadrenocortical syndrome, hypertension, diabetes, pregnant women, infections that cannot be controlled by antibacterial drugs such as chickenpox, measles, fungal infections, severe osteoporosis, etc.

Precautions for children: Children should be very cautious when using adrenocortical hormones for a long time. Exceptions are adrenocortical hypofunction and congenital adrenal hyperplasia. Precautions for pregnancy and lactation: 1. Medication during pregnancy: This product can pass through the placenta. Animal experimental studies have confirmed that administration during pregnancy can increase the incidence of cleft palate, placental insufficiency, spontaneous abortion and intrauterine growth retardation. It can increase the incidence of placental insufficiency, neonatal weight loss or stillbirth. 2. Medication during lactation: Since this product can be excreted in breast milk, it has adverse effects on infants, such as growth inhibition and adrenal cortical function inhibition. 3. Pregnant and lactating women should avoid using it as much as possible after weighing the pros and cons. Precautions for the elderly: Elderly patients are prone to hypertension and diabetes when using glucocorticoids. Elderly patients, especially postmenopausal women, are prone to aggravating osteoporosis when using glucocorticoids.

⑴ Nonsteroidal anti-inflammatory analgesics can enhance its ulcerogenic effect. ⑵ It can enhance the hepatotoxicity of acetaminophen. ⑶ When used in combination with amphotericin B or carbonic anhydrase inhibitors, it can aggravate hypokalemia. Long-term use with carbonic anhydrase inhibitors is prone to hypocalcemia and osteoporosis. ⑷ When used in combination with protein anabolic hormones, it can increase the incidence of edema and aggravate acne. ⑸ When used in combination with anticholinergics (such as atropine) for a long time, it can cause increased intraocular pressure. ⑹ Tricyclic antidepressants can aggravate the mental symptoms caused by it. ⑺ When used in combination with hypoglycemic drugs such as insulin, the dose of hypoglycemic drugs should be appropriately adjusted because it can increase the blood sugar of diabetic patients. ⑻ Thyroid hormones can increase its metabolic clearance rate, so when thyroid hormones or antithyroid drugs are used in combination with it, the dose of the latter should be appropriately adjusted. ⑼ When used in combination with contraceptives or estrogen preparations, it can enhance its therapeutic effects and adverse reactions. ⑽ When used in combination with cardiac glycosides, it can increase the toxicity of digitalis and the occurrence of arrhythmias. ⑾ When used in combination with potassium-excreting diuretics, it can cause severe hypokalemia and weaken the sodium-excreting and diuretic effects of diuretics due to water and sodium retention. ⑿ When used in combination with ephedrine, it can enhance its metabolic clearance. ⒀ When used in combination with immunosuppressants, it can increase the risk of infection and may induce lymphoma or other lymphoproliferative diseases. ⒁ It can increase the metabolism and excretion of isoniazid in the liver, and reduce the blood concentration and efficacy of isoniazid. ⒂ It can promote the metabolism of mexiletine in the body and reduce the blood concentration. ⒃ When used in combination with salicylates, it can reduce the concentration of plasma salicylate. ⒄ When used in combination with growth hormone, it can inhibit the latter's growth-promoting effect.

Keep away from light and store in a sealed container.

20ml:0.1g

36 months

Jilin Aodong Pharmaceutical Industry Group Yanji Co., Ltd.

• Founded in:

  1998-09-24

• Address:

  No. 389, Changbai Road, High-tech Development Zone, Yanji City, Jilin Province

• Tax NO.:

  912224017022762985

• Registered Funds:

  161.526808 yuan

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