Compound Sodium Chloride Injection

Compound sodium chloride is a drug for replenishing body fluids and regulating water and electrolyte balance. It contains water for injection, Na and Cl- ions and a small amount of K and Ca ions. Na and Cl- are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining the normal blood and extracellular fluid volume and osmotic pressure of the human body. The normal blood Na concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the plasma Na content plays a decisive role in osmotic pressure. The normal serum Cl- concentration is 98-106mmol/L. The human body mainly regulates through the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure. In addition to the above effects, compound sodium chloride can also supplement a small amount of potassium ions and calcium ions.

This product is a compound preparation, its components are 0.85% sodium chloride, 0.03% potassium chloride and 0.033% calcium chloride.

This product is a colorless, clear liquid with a slightly salty taste.

① Water loss due to various reasons, including hypotonic, isotonic and hypertonic water loss; ② Hyperosmotic non-ketotic coma, the use of isotonic or hypotonic sodium chloride can correct water loss and hyperosmotic state; ③ Hypochloremic metabolic alkalosis. When the patient cannot eat or eats less for some reason and needs to supplement the daily physiological needs, sodium chloride injection or compound sodium chloride injection can generally be given. Because this product contains very little potassium, hypokalemia needs to be supplemented as needed

When treating dehydration, the amount, type, route and speed of fluid replacement should be determined according to the degree and type of dehydration. (1) Hypertonic dehydration When hypertonic dehydration occurs, the osmotic concentration of the patient's brain cells and cerebrospinal fluid increases. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to drop too quickly, cerebral edema may occur. Therefore, it is generally believed that within the first 48 hours of treatment, the plasma sodium concentration should not drop by more than 0.5mmol/L per hour. If the patient is in shock, sodium chloride injection should be given first, and colloid should be supplemented as appropriate. When the shock is corrected, blood Na+155mmol/L, and plasma osmotic concentration is 350mOsm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mOsm/L, 0.9% sodium chloride injection should be used instead. The total amount of fluid replacement is calculated according to the following formula for reference: [blood Na+ concentration (mmol/L) - 142] Required fluid replacement (L) = ───────────── × 0.6 × body weight (Kg) Blood Na+ concentration (mmol/L) Generally, half of the amount is replenished on the first day, and the remaining amount is replenished within the next 2 to 3 days, and adjusted according to cardiopulmonary and renal function. (2) Isotonic dehydration principle is to give isotonic solutions, such as 0.9% sodium chloride injection or compound sodium chloride injection, but the Cl- concentration of the above solutions is significantly higher than that of plasma. Large-scale use alone can cause hyperchloremia. Therefore, 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% sodium lactate can be prepared in a ratio of 7:3 and then replenished. The latter has a Cl- concentration of 107mmol/L and can correct metabolic acidosis. The amount of fluid replacement can be calculated according to body weight or hematocrit for reference. ① Calculate the amount of fluid replacement based on body weight (L) = (weight loss (kg) × 142) / 154; ② Calculate the amount of fluid replacement based on hematocrit (L) = (actual hematocrit - normal hematocrit × body weight (kg) × 0.2) / normal hematocrit. Normal hematocrit is 48% for men and 42% for women. (3) Hypotonic dehydration In severe hypotonic dehydration, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid Na+ concentrations and osmotic concentrations to rise rapidly, brain cell damage may occur. It is generally believed that when blood Na+ is lower than 120mmol/L, treatment should increase the blood Na+ at a rate of 0.5mmol/L per hour and not more than 1.5mmol/L per hour. When blood Na+ is lower than 120mmol/L or central nervous system symptoms occur, 3% to 5% sodium chloride injection can be slowly dripped. It is generally required to increase the blood Na+ concentration to above 120mmol/L within 6 hours. Sodium supplement amount (mmol/L) = [142-actual blood Na+ concentration (mmol/L)] × body weight (kg) × 0.2. When blood Na+ rises to above 120-125mmol/L, isotonic solution can be used instead or hypertonic glucose injection or 10% sodium chloride injection can be added to isotonic solution as appropriate. (4) For hypochloremic alkalosis, 0.9% sodium chloride injection or compound sodium chloride injection (Ringer's solution) 500-1000ml is given, and the dosage is determined according to the degree of alkalosis.

Generally, there are no adverse reactions. Improper use may result in: (1) Dosing too quickly or excessively may lead to increased blood pressure, headache, and dizziness. (2) Weight gain and edema. (3) Accelerated heart rate, chest tightness, difficulty breathing, and wheezing in the lungs.

(1) Heart failure. (2) Pulmonary edema. (3) Brain edema and increased intracranial pressure. (4) Cirrhosis with ascites. (5) Oliguria in acute renal failure; poor response to diuretics in chronic renal failure. (6) Hypernatremia.

1. When used in combination with amphotericin B, it may cause turbidity, precipitation, or discoloration. 2. It is contraindicated to use with reserpine, polymyxin B sulfate, polymyxin E sulfate, and cephalosporin I.

Keep away from light and store in a sealed container.

500ml

Sichuan Kelun Pharmaceutical Co., Ltd.

• Founded in:

  2002-05-29

• Address:

  South 2nd Road, Xindu Satellite City Industrial Development Zone, Chengdu

• Tax NO.:

  9151010020260067X4

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  1,601,497,373 yuan

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