Labetalol Hydrochloride Tablets
Function and Efficacy
A drug that blocks both alpha and beta receptors. It has weak intrinsic activity and membrane stabilizing effects. The effect of blocking beta receptors is 4-8 times that of blocking alpha receptors; the effect of blocking beta 1 receptors is 1/4 of that of propranolol, and the effect of blocking beta 2 receptors is 1/17-1/11 of that of propranolol. This product is slightly stronger in blocking beta 1 receptors than in blocking beta 2 receptors and beta 1 receptors. At equivalent doses, its heart rate slowing effect is milder than that of propranolol, and its antihypertensive effect occurs faster. The vasodilation caused by this product blocking alpha receptors is also involved in the antihypertensive and anti-anginal mechanisms. Compared with simple beta receptor blockers, this drug has a stronger antihypertensive effect during standing and exercise tests. In addition, it can increase renal blood flow, while propranolol reduces it.
Ingredients
Active ingredient: Labetalol hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Labetalol hydrochlorideIngredients |
A drug that has both alpha and beta receptor blocking effects. It has weak intrinsic activity and membrane stabilizing effects. The effect of blocking beta receptors is 4-8 times that of blocking alpha receptors; the effect of blocking beta1 receptors is 1/4 of propranolol, and the effect of blocking beta2 receptors is 1/17-1/11 of propranolol. This product has a slightly stronger effect in blocking beta1 receptors than in blocking beta2 receptors. At equivalent doses, its heart rate slowing effect is milder than that of propranolol, and its antihypertensive effect occurs faster. The vasodilation caused by this product blocking alpha receptors is also involved in the antihypertensive and anti-anginal mechanisms. Compared with simple beta receptor blockers, this drug has a stronger antihypertensive effect during standing and exercise tests. In addition, it can increase renal blood flow, while propranolol reduces it. More |
32780-64-6 | 35 |
Appearance
This product is white or off-white tablets.
Indication
It is suitable for the treatment of mild to severe hypertension and angina pectoris; intravenous injection can treat hypertensive crisis. It is suitable for: 1. Mild to moderate hypertension. 2. Pregnant women with hypertension or preeclampsia. 3. Pheochromocytoma. 4. Rapid hypertension and hypertensive crisis. 5. Control of hypotension during general anesthesia.
Usage and Dosage
Oral administration: The usual dosage is 100-200 mg each time, 2-3 times a day, taken after meals. In case of severe hypertension, the dosage can be increased to 400 mg each time, 3-4 times a day. The daily dosage should not exceed 2400 mg.
Adverse Reactions
1. Common symptoms include dizziness, fatigue, hallucinations, gastrointestinal disorders (nausea, indigestion, abdominal pain, diarrhea), dry mouth, and tingling in the scalp. 2. Overdose may also cause tachycardia and acute renal failure. 3. Children, pregnant women, and patients with asthma and cerebral hemorrhage should not use intravenous injection. 4. Patients with angina pectoris should not stop taking the drug suddenly. 5. Dizziness, itching, fatigue, nausea, chest tightness, and orthostatic hypotension may occur in a few patients.
Precautions
Patients with cerebral hemorrhage, bradycardia, conduction block and bronchial asthma.
Drug Interactions
The combination with tricyclic antidepressants can increase the incidence of tremor, and cimetidine can increase the bioavailability of this drug. Reference: Cimetidine, diuretics, and other antihypertensive drugs can enhance the effect of this product.
Storage
Sealed and stored.
Packaging Specification
50mg
Manufacturer
Merro Pharmaceutical Co., Ltd.
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Founded in:
2015-06-11 -
Address:
No. 9, Yingsheng Road, Ganjingzi District, Dalian City, Liaoning Province -
Tax NO.:
912102007169138094 -
Registered Funds:
350 million yuan -
Website:
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Email: