Gentomycin Sulfate and Bismuth Carbonate Capsules

It has good effects on spores, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has good antibacterial effects on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but most methicillin-resistant strains are resistant to this product. It has poor effects on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-lactams, most of them can obtain synergistic antibacterial effects. Its mechanism of action is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly. Bismuth subcarbonate can play a protective antacid and astringent role in the gastrointestinal mucosa, and can achieve an antidiarrheal effect by reducing intestinal irritation, preventing excessive dehydration and water-salt metabolism disorders in the body.

This product is a compound preparation, and its components are: each tablet contains 40 mg (40,000 units) of gentamicin sulfate (calculated as gentamicin) and 600 mg of bismuth subcarbonate.

This product is a capsule, and the contents are white or slightly yellowish powder or granules.

Used for chronic ulcerative enteritis, dysentery, and acute enteritis.

Oral administration. Adults take 2-3 capsules at a time, 3 times a day; children take 1 capsule at a time, 3 times a day. For continuous medication, one course of treatment should not exceed 10 days.

1. Nausea, loss of appetite, vomiting, abdominal distension and other gastrointestinal symptoms and skin rash, serum aminotransferase elevation, etc. are rare. 2. Hearing loss, tinnitus or fullness in the ears (ototoxicity), hematuria, significantly reduced urination frequency or decreased urine volume, loss of appetite, extreme thirst (nephrotoxicity), unsteady gait, dizziness (ototoxicity, vestibular effects), dyspnea, drowsiness, extreme weakness (neuro-muscle blockade) are occasionally seen. 3. Long-term use of large doses can cause constipation, alkalosis and malabsorption syndrome.

Patients who are allergic to this product or other aminoglycoside antibiotics are contraindicated.

Precautions for children: Because this product has potential ototoxicity and nephrotoxicity, it should be used with caution in children. Precautions for pregnancy and lactation: Because the absorbed part of this product can enter the fetal circulation through the placenta, pregnant women should use it with caution. Lactating women should suspend breastfeeding during medication. Precautions for the elderly: Because this product has potential ototoxicity and nephrotoxicity, it should be used with caution in elderly patients.

1. When used in combination with other aminoglycosides or used successively, it may increase the possibility of ototoxicity, nephrotoxicity and neuromuscular blocking effects. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects. 2. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin or used successively, it may increase the possibility of ototoxicity and nephrotoxicity. 3. When used in combination with cephalothin, it may increase nephrotoxicity. 4. When used in combination with polymyxins or used successively, it may increase nephrotoxicity and neuromuscular blocking effects. 5. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or used successively to avoid aggravating nephrotoxicity or ototoxicity. 6. When used in combination with large doses of anti-pseudomonas penicillins (carbenicillin, ticarcillin, mezlocillin, azlocillin, piperacillin), gentamicin may be inactivated and should be used separately.

Keep away from light, sealed and stored in a dry place.

Each tablet contains gentamicin sulfate (calculated as gentamicin) 40 mg (40,000 units), bismuth subcarbonate 600 mg

24 months

Huludao Guodi Pharmaceutical Co., Ltd.

• Founded in:

  2000-06-29

• Address:

  Huludao Gaoqiao Economic Development Zone

• Tax NO.:

  91211404123720542A

• Registered Funds:

  16.18 million yuan

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