Cefazolin Sodium for Injection
Function and Efficacy
Cefazolin is a first-generation cephalosporin with a broad antibacterial spectrum. Except for Enterococcus and methicillin-resistant Staphylococcus, this product has good antibacterial activity against other Gram-positive cocci, and Streptococcus pneumoniae and hemolytic Streptococcus are highly sensitive to this product. Diphtheria Corynebacterium, anthrax Bacillus, Listeria and Clostridium are also very sensitive to this product. This product has good antibacterial activity against some Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae, but has poor antibacterial effect on Staphylococcus aureus. Salmonella typhi, Shigella and Neisseria are sensitive to this product, while other Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa are resistant. Enzyme-producing Neisseria gonorrhoeae is resistant to this product; Haemophilus influenzae is only moderately sensitive. Gram-positive anaerobes and some Gram-negative anaerobes are mostly sensitive to this product. Bacteroides fragilis is resistant.
Ingredients
Its chemical name is (6R,7R)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-7-[(1H-tetrazol-1-yl)acetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt Molecular formula: C14H13N8NaO4S3 Molecular weight: 476.50
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| CefazolinIngredients |
Cefazolin is a first-generation cephalosporin with a broad antibacterial spectrum. Except for Enterococcus and methicillin-resistant Staphylococcus, this product has good antibacterial activity against other Gram-positive cocci, and Streptococcus pneumoniae and hemolytic Streptococcus are highly sensitive to this product. Diphtheria Corynebacterium, anthrax Bacillus, Listeria and Clostridium are also very sensitive to this product. This product has good antibacterial activity against some Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae, but has poor antibacterial effect on Staphylococcus aureus. Salmonella typhi, Shigella and Neisseria are sensitive to this product, while other Enterobacteriaceae, Acinetobacter and Pseudomonas aeruginosa are resistant. Enzyme-producing Neisseria gonorrhoeae is resistant to this product; Haemophilus influenzae is only moderately sensitive. Gram-positive anaerobes and some Gram-negative anaerobes are mostly sensitive to this product. Bacteroides fragilis is resistant. More |
25953-19-9 | 5 |
Appearance
This product is white or off-white powder or crystalline powder; odorless.
Indication
It is suitable for the treatment of respiratory tract infections such as otitis media, bronchitis, pneumonia, urinary tract infections, skin and soft tissue infections, bone and joint infections, sepsis, infective endocarditis, hepatobiliary system infections, and infections of the eyes, ears, nose, and throat caused by sensitive bacteria. This product can also be used as a preventive medication before surgery.
Usage and Dosage
Common adult dose: slow intravenous push, intravenous drip or intramuscular injection, 0.5g-1g at a time, 2-4 times a day, severe infection can be increased to 6g a day (0.5g: 12 tubes; 1.0g: 6 tubes), divided into 2-4 intravenous administration. Common child dose: 50-100mg/kg a day, divided into 2-3 times of slow intravenous push, intravenous drip or intramuscular injection. When the creatinine clearance of patients with renal impairment is greater than 50ml/min
Adverse Reactions
1. The incidence of thrombophlebitis and pain in the intramuscular injection area after intravenous injection is less and milder than that of cephalothin. 2. The incidence of drug rash is 1.1%, the incidence of eosinophilia is 1.7%, and drug fever occasionally occurs. 3. Some patients may experience temporary elevation of serum aminotransferase and alkaline phosphatase. 4. Patients with renal impairment may experience encephalopathy when using high doses (12g per day) of this product. 5. Superinfection with Candida albicans is occasionally seen.
Precautions
This product is contraindicated in patients who are allergic to cephalosporins or have a history of anaphylactic shock or immediate reaction to penicillin.
Special Population Medication
Precautions for children: This product is not recommended for premature infants and newborns under 1 month old. Precautions for pregnancy and lactation: This product has a low content in breast milk. However, breastfeeding women should still suspend breastfeeding when taking the drug. Precautions for the elderly: The T1/2beta of this product in the elderly is significantly longer than that in young people. The dosage should be appropriately reduced or the dosing interval should be extended according to renal function.
Drug Interactions
1. This product is contraindicated with the following drugs and cannot be infused in the same bottle: amikacin sulfate, kanamycin sulfate, chlortetracycline hydrochloride, oxytetracycline hydrochloride, tetracycline hydrochloride, erythromycin gluconate, polymyxin B sulfate, colistin sodium methanesulfonate, pentobarbital, calcium gluconate, calcium gluconate. 2. This product can enhance the antibacterial effect in vitro when used in combination with gentamicin or amikacin. 3. This product may increase nephrotoxicity when used in combination with strong diuretics, and may increase the nephrotoxicity of the latter when used in combination with aminoglycoside antibiotics. 4. Probenecid can increase the blood concentration of this product and prolong its blood half-life.
Storage
Keep tightly closed in a cool, dark and dry place.
Packaging Specification
Calculated as C14H14N8O4S3 0.5g
Manufacturer
Shandong Lukang Pharmaceutical Co., Ltd.
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Founded in:
1993-02-15 -
Address:
No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province -
Tax NO.:
913700001659297311 -
Registered Funds:
880.229735 yuan -
Website:
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Email: