Cefoperazone Sodium for Injection

Cefoperazone is a third-generation cephalosporin, which has good antibacterial effect on Escherichia coli, Klebsiella, Proteus, Salmonella typhi, Shigella, Citrobacter and other Enterobacteriaceae and Pseudomonas aeruginosa, but has poor effect on Enterobacter aerogenes, Enterobacter cloacae, Salmonella typhimurium and Acinetobacter. Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis are highly sensitive to this product.

Cefoperazone Sodium

This product is white or off-white crystalline powder or freeze-dried block or powder; odorless.

It is suitable for various infections caused by sensitive bacteria such as pneumonia and other lower respiratory tract infections, urinary tract infections, biliary tract infections, skin and soft tissue infections, sepsis, peritonitis, pelvic infections, etc. The latter two are suitable for combined use with anti-anaerobic drugs.

It can be injected intramuscularly, intravenously or intravenously. Adult dosage: For general infection, 1.2g (1-2 vials) once, once every 12 hours (twice a day); for severe infection, 2-3g (2-3 vials) once, once every 8 hours (three times a day). For patients receiving hemodialysis, a supplementary dose should be given after dialysis. The daily dosage for adults should not exceed 9g (9 vials), but in immunocompromised patients with severe infection, the dosage can be increased to 12g (12

1. Skin rash is more common, reaching 2.3% or more. 2. A small number of patients may also experience diarrhea, abdominal pain, eosinophilia, and mild neutropenia. 3. Transient increase in serum aminotransferase, alkaline phosphatase, urea nitrogen, or serum creatinine. 4. Thrombocytopenia and prolonged prothrombin time may be seen in individual cases. Occasional bleeding can be prevented or controlled with vitamin K. 5. Dysbacteriosis may occur in a small number of patients. 6. Those who drink alcohol or take alcoholic drugs or beverages during the use of this product may experience a disulfiram-like reaction.

This product is contraindicated in patients who are allergic to cephalosporins or have a history of allergic shock and immediate reaction to penicillin.

1. This product has a synergistic effect on certain sensitive strains of Enterobacteriaceae and Pseudomonas aeruginosa when used in combination with aminoglycoside antibiotics (gentamicin and tobramycin). 2. This product can produce hypoprothrombinemia and thrombocytopenia. When used simultaneously with the following drugs, it may cause bleeding: anticoagulant heparin, coumarin or indandione derivatives, thrombolytic drugs, non-steroidal anti-inflammatory analgesics (especially aspirin, diflunisal or other salicylic acid preparations) and sulfinpyrazone, etc. 3. The chemical structure of this product contains a methylthiotetrazolyl side chain. Therefore, during the use of this product, drinking alcohol or intravenous injection of ethanol-containing drugs will inhibit the activity of acetaldehyde dehydrogenase, causing acetaldehyde accumulation in the blood, and causing disulfiram-like reactions such as drowsiness and hallucinations. Therefore, during the medication period and within 5 days after stopping the medication, patients cannot drink alcohol, take oral or intravenous injection of ethanol-containing drugs. 4. When this product is used in combination with aminoglycoside antibiotics, it cannot be dripped in the same bottle because it may affect the antibacterial activity of each other. 5. This product is contraindicated with the following drug injections: amikacin, gentamicin, kanamycin B, doxycycline, meclofenoxate, amarin (Bianmailing), diphenhydramine, potassium magnesium aspartate, hydroxyzine hydrochloride (Antalol), procainamide, aminophylline, prochlorperazine, cytochrome C, pentazocine (Zhentongxin), aprotinin, etc.

Keep tightly closed in a cool place.

Calculated as C25H27N9O8S2 1.0g

Shandong Lukang Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-15

• Address:

  No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province

• Tax NO.:

  913700001659297311

• Registered Funds:

  880.229735 yuan

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