Cephalexin Granules

1 Pharmacology Cephalexin is a first-generation cephalosporin with an antibacterial spectrum similar to that of cephalothin, but its antibacterial activity is poorer than that of the latter. Except for Enterococcus and methicillin-resistant Staphylococci, most strains of Streptococcus pneumoniae, hemolytic Streptococcus, and Staphylococcus aureus that produces or does not produce penicillinase are sensitive to this product. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; this product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis are resistant to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are moderately sensitive to this product. 2 Toxicity The oral median lethal dose of cephalexin in mice is 2600 mg/kg.

Cephalexin

This product is a granule with flavoring agent added.

It is suitable for acute tonsillitis, pharyngitis, otitis media, sinusitis, bronchitis, pneumonia and other respiratory tract infections, urinary tract infections and skin and soft tissue infections caused by sensitive bacteria. This product is an oral preparation and should not be used for severe infections.

Adult dosage: Oral, generally 250-500 mg (50 mg: 5-10 packets; 0.125 g: 2-4 packets), 4 times a day, the highest dose is 4 g (50 mg: 80 packets; 0.125 g: 32 packets) per day. Patients with renal impairment should reduce the dosage according to the degree of renal impairment. Patients with simple cystitis, skin and soft tissue infections, and streptococcal pharyngitis should take 0.5 g every 12 hours (10 packets of 50 mg;

1 Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2 Allergic reactions such as rash and drug fever. Occasionally, anaphylactic shock may occur. 3 Nervous system reactions such as dizziness, diplopia, tinnitus, convulsions, etc. 4 Renal damage may occasionally occur during the use of this product. 5 Occasionally, patients have elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported.

It is contraindicated in patients who are allergic to cephalosporins or have a history of anaphylactic shock or immediate reaction to penicillin.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: This product can pass through the placenta, so pregnant women should use it with caution; this product is also excreted through breast milk. Although there are no reports of problems with the use of cephalosporins in lactating women, its use still needs to weigh the pros and cons. Precautions for the elderly: This experiment has not been conducted and there are no reliable references.

1. When used in combination with cholestyramine, the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the effect of this product.

Keep away from light, seal tightly and store in a cool dark place.

Calculated as C16H17N3O4S 50 mg

24 months

Shandong Lukang Pharmaceutical Co., Ltd.

• Founded in:

  1993-02-15

• Address:

  No. 88, Deyuan Road, Jining High-tech Zone, Shandong Province

• Tax NO.:

  913700001659297311

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  880.229735 yuan

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