Indapamide Tablets

It is a sulfonamide diuretic that works by inhibiting the reabsorption of water and electrolytes in the dilution segment of the distal renal tubular cortex. The antihypertensive effect is unclear, and its diuretic effect cannot explain the antihypertensive effect, because the dose at which the antihypertensive effect occurs is much smaller than the dose of the diuretic effect. Possible mechanisms include the following aspects: regulating calcium influx into vascular smooth muscle cells; stimulating the synthesis of prostaglandins PGE2 and prostaglandins PGI2; reducing the hypersensitivity of blood vessels to vasopressor amines, thereby inhibiting vasoconstriction. This product has little or no effect on cardiac output, heart rate and heart rhythm when lowering blood pressure. Long-term use of this product rarely affects glomerular filtration rate or renal blood flow. This drug does not affect the metabolism of blood lipids and carbohydrates.

Indapamide

This product is a sugar-coated tablet, which appears white after removing the sugar coating.

Used to treat high blood pressure.

The usual adult oral dose is 2.5 mg once a day.

Relatively mild and short-lived, and dose-related. 1 Less common are: diarrhea, headache, loss of appetite, insomnia, nausea, orthostatic hypotension. 2 Less common are: allergic reactions such as rash and itching; hyponatremia, hypokalemia, and hypochloremic alkalosis.

Allergic to sulfonamides, severe renal insufficiency, hepatic encephalopathy or severe hepatic insufficiency, hypokalemia.

Precautions for children: This experiment has not been conducted and there are no reliable references. Precautions for pregnancy and lactation: Diuretics can cause fetal placental ischemia and fetal malnutrition. It is generally believed that pregnant women should avoid taking thiazide and related diuretics, and do not use such diuretics to treat physiological edema during pregnancy. Due to the lack of research data on the entry of drugs into breast milk, mothers taking the drug should avoid breastfeeding. Precautions for the elderly: Elderly patients are more sensitive to antihypertensive effects and electrolyte changes, and need to be monitored carefully when using this product.

1. When this product is used together with adrenal cortical hormone, its diuretic and natriuretic effects are weakened; 2. When this product is used together with amiodarone, it is easy to cause arrhythmia due to low blood potassium; 3. When this product is used together with oral anticoagulants, the anticoagulant effect is weakened; 4. When this product is used together with non-steroidal anti-inflammatory analgesics, its natriuretic effect is weakened; 5. When this product is used together with dopamine, its diuretic effect is enhanced; 6. When this product is used together with other types of antihypertensive drugs, its antihypertensive effect is enhanced; 7. When this product is used together with sympathomimetics, its antihypertensive effect is weakened; 8. When this product is used together with lithium, it can increase blood lithium concentration and show signs of overdose; 9. When used together with large doses of salicylates, dehydrated patients may develop acute renal failure; 10. When used together with metformin, lactic acidosis is likely to occur.

Keep in a light-proof and airtight container.

2.5mg

24 months.

Shandong FANGMING Pharmaceutical Group Co., Ltd.

• Founded in:

  2000-07-07

• Address:

  Fangming Section, Huanghe Road, Dongming County, Shandong Province

• Tax NO.:

  91371700724268643E

• Registered Funds:

  216.829902 yuan

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