Nefopam Hydrochloride Injection
Function and Efficacy
[Pharmacology and Toxicology] This product is a new type of non-narcotic analgesic, with mild antipyretic and muscle relaxant effects. The chemical structure belongs to cyclized o-methylbenzylamine. Therefore, it does not have the characteristics of non-steroidal anti-inflammatory drugs, nor is it an opioid receptor agonist. It is effective for moderate and severe pain. An intramuscular injection of 20 mg of this product is equivalent to the effect of 12 mg of morphine. It has a mild respiratory depressant effect. It has no inhibitory effect on the circulatory system. There is no tolerance and dependence. Acute toxicity LD50 (mg/kg): mice, oral 66.6; intraperitoneal 28.7; intravenous 21.9. Rats, oral 178; intramuscular injection 56.9. [Pharmacokinetics] This product takes effect 5 to 10 minutes after intramuscular injection, Tmax 1.5 hours, and the effect lasts 2 to 8 hours. T1/24 to 8 hours, plasma protein binding rate 71% to 76%. It loses its pharmacological activity due to liver metabolism, most of it is excreted through the kidneys, less than 5% of the original drug, and a small amount is excreted with feces.
Ingredients
The main ingredient of this product is: Nefopam hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Nefopam hydrochlorideIngredients |
A new type of non-narcotic analgesic, with mild antipyretic and muscle relaxant effects. It is effective for moderate and severe pain. An intramuscular injection of 20 mg of this product is equivalent to the effect of 12 mg of morphine. It has a mild respiratory depressant effect. It has no depressant effect on the circulatory system. It has no tolerance and dependence. More |
23327-57-3 | 12 |
Appearance
This product is a colorless clear liquid.
Indication
It is used for postoperative analgesia, cancer pain, acute traumatic pain. It is also used for visceral smooth muscle colic such as acute gastritis, biliary ascariasis, ureteral stones, etc. It is also used as an auxiliary drug for local anesthesia, acupuncture anesthesia, etc.
Usage and Dosage
Intramuscular or intravenous injection: 20 mg at a time, or every 3 to 4 hours if necessary.
Adverse Reactions
When the effects occur, there are often drowsiness, nausea, sweating, dizziness, headache, etc. But it usually does not last long. Occasionally, dry mouth, dizziness, and rash are seen.
Precautions
It is contraindicated in patients with severe cardiovascular disease, myocardial infarction or convulsions.
Drug Interactions
Overdose of this product may cause excitement and should be treated with tranquilizers.
Storage
Keep away from light and store in a sealed container.
Packaging Specification
2ml:20mg
Manufacturer
Shandong FANGMING Pharmaceutical Group Co., Ltd.
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Founded in:
2000-07-07 -
Address:
Fangming Section, Huanghe Road, Dongming County, Shandong Province -
Tax NO.:
91371700724268643E -
Registered Funds:
216.829902 yuan -
Website:
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Email: