Cimetidine tablets

1. Pharmacology: It mainly acts on H2 receptors on parietal cells, competitively inhibiting histamine. It can inhibit basal gastric acid secretion. It can also inhibit gastric acid secretion stimulated by food, histamine, pentagastrin, caffeine and insulin. 2. Toxicology: Acute toxicity, oral LD50 for mice is 3190-3280 mg/Kg, and oral LD50 for rats is 5840-7500 mg/Kg. Subacute and chronic toxicity tests on rats and dogs have shown that this product has a mild anti-androgen effect and can cause a decrease in the weight of the prostate and seminal vesicles. Milk secretion occurs, but disappears after drug withdrawal. It has no mutagenic, carcinogenic, or teratogenic effects. It also has no dependence and drug resistance.

Each tablet of this product contains the main ingredient, 0.2 g of imipenem, and the auxiliary materials are starch, dextrin, magnesium stearate, and sodium carboxymethyl starch.

This product is white or off-white crystalline powder; almost odorless and bitter.

Used to relieve stomach pain, heartburn and acid reflux caused by excessive stomach acid.

Adults, oral: 0.2g/time, 3 times/day, take after meal, and take 0.4g before bedtime; or 0.4g/time, 2 times/day; or 0.8g once before bedtime. Intravenous injection: 0.2g/time, slow injection, 4-6 times/day. Intravenous drip: 0.4g-0.6g, 2 times/day. Children: Oral or intramuscular injection, 5mg-10mg/kg each time, 2-4 times/day.

The adverse reactions of this product are generally uncommon, and usually disappear after continuing the medication or stopping the medication. 1 The more common adverse reactions include diarrhea, dizziness, fatigue, headache and rash. 2 This product has a mild anti-androgenic effect. When the dosage is large (more than 1.6g per day), it can cause male breast development, female galactorrhea, loss of libido, impotence, decreased sperm count, etc., which will disappear after stopping the medication. 3 This product can pass the blood-cerebrospinal fluid barrier and has certain neurotoxicity. Mental disorders are occasionally seen, which are more common in the elderly, young children, and seriously ill patients, and can be recovered within 48 hours after stopping the medication. When treating gastrointestinal complications of alcoholics, delirium tremens may occur, which is similar to alcohol withdrawal syndrome; 4 Rare adverse reactions of this product include: allergic reactions, fever, joint pain, muscle

It is contraindicated for those who are allergic to this product.

Precautions for children: Children should use the product under the guidance of a physician. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients should use the product under the guidance of a physician.

When used in combination with warfarin, theophylline, phenytoin and other drugs, the dosage should be reduced. Antacids such as aluminum hydroxide or metoclopramide can reduce the absorption of this product. It can reduce the effects of sucralfate, tetracycline, etc. When used in combination with opioids, patients with chronic renal failure may experience respiratory depression, mental confusion and disorientation, etc., and the dosage of opioid preparations should be reduced. 1. This product is a liver drug enzyme inhibitor, which reduces the activity of drug enzymes by binding to cytochrome P450 through its imidazole ring, and can also reduce liver blood flow. Therefore, when this product is used in combination with propranolol, the latter's blood drug concentration can be increased and the heart rate can be slowed down at rest; when used in combination with phenytoin sodium or other hydantoins, the latter's blood drug concentration can be increased, which may lead to phenytoin sodium poisoning. When it must be used in combination, the blood drug concentration of phenytoin sodium should be measured after 5 days to adjust the dosage. 2. When this product is used in combination with cyclosporine, the latter's blood drug concentration can be increased. 3. When this product is used in combination with moclobemide, the latter's blood concentration can be increased. 4. When this product is used in combination with aspirin, the solubility of aspirin can be increased, absorption can be increased, and the effect can be enhanced. 5. When this product is used in combination with methadone, the latter's blood concentration can be increased, which may cause the risk of overdose. 6. When this product is used in combination with tacrine, the latter's blood concentration can be increased, which may cause the risk of overdose. 7. When this product is used in combination with benzodiazepines (such as diazepam, nitrazepam, flunitrazepam, chlordiazepoxide, midazolam, triazolam, etc.), it can inhibit the latter's liver metabolism, increase its blood concentration, aggravate its sedation and other central nervous system depression symptoms, and may develop into respiratory and circulatory failure. However, lorazepam, oxazepam and temazepam do not seem to be affected. 8. When this product is used in combination with coumarin anticoagulants, the latter's excretion rate from the body can be reduced, and the prothrombin time can be further prolonged, leading to a bleeding tendency. When the two are used in combination, close attention should be paid to changes in the condition and the dosage of the anticoagulant should be adjusted. 9. This product can increase the absolute bioavailability of verapamil (Isapamil). Since verapamil can cause serious adverse reactions, although rare, it should still be paid attention to. 10. When this product is used in combination with theophylline, the latter's demethylation metabolic clearance rate can be reduced by 20-30%, and the blood concentration of the drug can be increased. 11. Patients who take digoxin and quinidine at the same time should not use this product at the same time, because this product can inhibit the metabolism of quinidine, and the latter can displace digoxin from its binding site, resulting in an increase in the blood concentrations of both quinidine and digoxin. 12. When this product is used in combination with carbamazepine, the latter's blood concentration can be increased, which may lead to the risk of overdose. 13. When this product is used in combination with lidocaine (for parenteral use), the latter's blood concentration can be increased, thereby increasing the risk of adverse reactions to the nervous system and heart. When the two are used in combination, the lidocaine dose needs to be adjusted and clinical monitoring needs to be strengthened. 14. When this product is used in combination with caffeine, it can slow down the metabolism of caffeine, enhance its effects, and easily cause toxic reactions. Patients with gastric ulcers should avoid caffeine, and caffeine and caffeinated beverages should be prohibited when taking this product. 15. When this product is used in combination with antacids (such as aluminum hydroxide and magnesium oxide), it can relieve the pain of duodenal ulcers, but the absorption of cimetidine may be reduced, so it is generally not recommended to use the two together. If they must be used together, the two should be taken at least 1 hour apart. 16. When used in combination with metoclopramide, the blood concentration of this product can be reduced. If the two need to be used together, the dose of this product should be appropriately increased. 17. Since sucralfate needs to be hydrolyzed by gastric acid to work, and this product inhibits gastric acid secretion, the efficacy of sucralfate may be reduced when the two are used together. 18. This product increases the pH value of gastric juice. When used in combination with tetracycline, it can reduce the dissolution rate of tetracycline, reduce absorption, and weaken the effect; but the hepatic enzyme inhibition of this product may increase the blood concentration of tetracycline. 19. When this product is used in combination with ketoconazole, it can interfere with the absorption of the latter and reduce its antifungal activity, but taking some acidic beverages at the same time can avoid the above changes. 20. When this product is used in combination with captopril, it may cause psychotic symptoms. 21. Since this product has a neuromuscular blocking effect similar to aminoglycoside drugs, it may cause respiratory depression or respiratory arrest when used in combination with aminoglycoside antibiotics. 22. This product should be avoided from being used simultaneously with central anticholinergic drugs to prevent aggravation of central nervous system toxicity. 23. When this product is used in combination with carmustine, it can increase bone marrow toxicity. 24. When this product is used in combination with opioids, there have been reports of adverse reactions such as respiratory depression, mental confusion, and disorientation in patients with chronic renal failure.

Keep sealed.

0.2 g

36 months

Shandong FANGMING Pharmaceutical Group Co., Ltd.

• Founded in:

  2000-07-07

• Address:

  Fangming Section, Huanghe Road, Dongming County, Shandong Province

• Tax NO.:

  91371700724268643E

• Registered Funds:

  216.829902 yuan

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