Sodium Nitroprusside for Injection

Sodium nitroprusside is a fast-acting and short-acting vasodilator. It has a direct dilating effect on both arterial and venous smooth muscles, but does not affect the contraction of the uterus, duodenum or myocardium. Vasodilation reduces peripheral vascular resistance, thus having a hypotensive effect. Vasodilation reduces both the preload and afterload of the heart and improves cardiac output, so it is beneficial for heart failure. Reducing afterload can reduce the impedance of the aorta and left ventricle during valvular insufficiency and reduce reflux.

Sodium nitrosoferricyanide dihydrate

This product is pink crystalline powder. The aqueous solution is unstable when placed on ice and decomposes rapidly under light.

1. Used for emergency hypotension in hypertensive emergencies, such as hypertensive crisis, hypertensive encephalopathy, malignant hypertension, paroxysmal hypertension before and after pheochromocytoma surgery, etc. It can also be used for controlled hypotension during surgical anesthesia. 2. Used for acute heart failure, including acute pulmonary edema. It is also used for acute heart failure during acute myocardial infarction or valvular (mitral or aortic) insufficiency.

Before use, dissolve 50 mg (1 vial) of this product in 5 ml of 5% glucose solution, dilute it in 250 ml to 1000 ml of 5% glucose solution, and drip it intravenously in a light-proof infusion bottle. 1 Common dosage for adults: intravenous drip, start with 0.5 μg/kg per minute based on body weight. According to the therapeutic response, increase by 0.5 μg/kg per minute, and gradually adjust the dose. The common dose is 3 μg/kg per minute based on body weight. The maximum dose is 10 μg/kg per minute based on body weight. The total amount is 3.5 mg/kg per minute based on body weight. It is used for short-term controlled hypotension during anesthesia, and the drip volume is 0.5 mg/kg per minute based on body weight. 2 Common dosage for children: intravenous drip, 1.4 μg/kg per minute based on body weight. Gradually adjust the dosage according to the effect.

1. The toxicity of this product comes from its metabolites, cyanide and thiocyanate. Cyanide is an intermediate metabolite and thiocyanate is the final metabolite. If cyanide cannot be converted to thiocyanate normally, poisoning may occur even if the blood concentration of thiocyanate is normal. 2. If this product is suddenly discontinued during anesthesia to control blood pressure, especially when the blood concentration is high and the drug is suddenly discontinued, rebound blood pressure may occur. 3. Adverse reactions may occur in the following three situations. (1) Blood pressure drops too quickly and too drastically, resulting in dizziness, sweating, headache, muscle twitching, nervousness or anxiety, irritability, stomach pain, reflex tachycardia or arrhythmia. The occurrence of symptoms is related to the speed of intravenous administration and has little to do with the total amount. (2) In case of thiocyanate poisoning or overdose, movement disorders, blurred vision, delirium, dizziness, headache, loss of consciousness, nausea, vomiting, tinnitus, and shortness of breath may occur. (3) Skin: Photosensitivity is related to the course of treatment and dosage. Slate blue pigmentation on the skin takes a long time (1 to 2 years) to subside after stopping the drug. Other allergic rashes subside quickly after stopping the drug. (4) In case of cyanide poisoning or overdose, loss of reflexes, coma, distant heart sounds, hypotension, loss of pulse, pink skin, shallow breathing, and dilated pupils may occur.

This product is contraindicated in patients with compensated hypertension such as arteriovenous shunt or aortic coarctation.

Precautions for children: intravenous drip, 1.4μg/kg per minute based on body weight. Gradually adjust the dosage according to the effect. Precautions for pregnancy and lactation: Contraindicated for pregnant women. Precautions for the elderly: When using this product, the elderly should pay attention to the effect of decreased renal function on the excretion of this product as they age. The elderly are also more sensitive to antihypertensive reactions, so the dosage should be reduced as appropriate.

1. When used with other antihypertensive drugs, blood pressure can drop dramatically. 2. When used with dobutamine, cardiac output can be increased and pulmonary capillary pressure can be reduced. 3. When used with sympathomimetic amines, the antihypertensive effect of this product is weakened.

Keep away from light and sealed. Valid for two years.

50mg

24 months

Wuhan Humanwell Pharmaceutical Co., Ltd.

• Founded in:

  1997-06-02

• Address:

  No. 8, Shenghuyuan Road, East Lake New Technology Development Zone, Wuhan, Hubei

• Tax NO.:

  914201003001966747

• Registered Funds:

  260 million yuan

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