Compound Lophatherum gracile tablets Ⅰ
Function and Efficacy
This product was administered orally to experimental dogs with renal hypertension at a dose of 0.2g/kg, which significantly reduced blood pressure from 190/142 to 153/98mmHg 2 hours after oral administration. This product was administered orally to dogs and cats at 0.2 and 0.4g/kg, which slowed the heart rate 20 minutes later and lasted for 5 hours. This product was administered orally to rats at 0.3 and 0.6g/kg, which significantly counteracted arrhythmias caused by aconitine, calcium chloride and coronary artery ligation, and its anti-arrhythmic mechanism may be related to the effect on calcium ion influx. This product was administered orally to mice at 0.6 and 1.2g/kg, which reduced spontaneous activity in mice, and had a synergistic effect with sodium pentobarbital, causing the mice to lose their righting reflex.
Ingredients
Apocynum venetum, wild chrysanthemum, tetrandrachidia tertium, guanidine sulfate, hydralazine, chlordiazepoxide, and vitamin B1.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| D-TetrandrineIngredients |
It can lower blood pressure, slow heart rate, counteract arrhythmias, reduce spontaneous activity, and work synergistically with sodium pentobarbital More |
518-34-3 | 3 | |
| GUANOXAN SULFATEIngredients |
It can lower blood pressure, slow heart rate, counteract arrhythmias, reduce spontaneous activity, and work synergistically with sodium pentobarbital More |
5714-04-5 | 1 | |
| HydralazineIngredients |
It can lower blood pressure, slow heart rate, counteract arrhythmias, reduce spontaneous activity, and work synergistically with sodium pentobarbital More |
86-54-4 | 0 | |
| Thiamine chlorideIngredients |
It can lower blood pressure, slow heart rate, counteract arrhythmias, reduce spontaneous activity, and work synergistically with sodium pentobarbital More |
59-43-8 | 9 |
Appearance
This product is a sugar-coated tablet.
Indication
Used for hypertension.
Usage and Dosage
Oral, usual dosage: three times a day, two tablets each time. Maintenance dosage: two tablets a day after blood pressure drops
Adverse Reactions
Oral administration of Lophatherum preparations often causes bowel sounds, diarrhea, occasional stomach pain, dry mouth and other adverse reactions, and some patients experience asthma and liver pain; cardiotoxicity is mainly bradycardia and premature contractions. Excessive use can cause sedation, drowsiness, fatigue, etc., and can also cause an increase in blood uric acid.
Precautions
It is contraindicated for those who are allergic to this product.
Special Population Medication
Precautions for children: Reduce the dosage or follow the doctor's advice. Precautions for pregnancy and lactation: This product is not the first choice for pregnant and lactating women with hypertension. Precautions for the elderly: Not yet clear.
Drug Interactions
-Atropine: can partially counteract the antihypertensive effect of Apocynum venetum leaves. -Diphenhydramine: can block the antihypertensive effect of Apocynum venetum leaves by more than 50%. Other antihypertensive drugs: Apocynum venetum can be used in combination with external Chinese medicine patches such as Li's Medicinal Patch, Jiangya Shen Patch, and Xuanya Patch to enhance the antihypertensive effect. For other drug interactions, please consult your doctor or pharmacist.
Storage
Keep tightly closed.
Packaging Specification
Compound
Validity Period
24 months
Manufacturer
Sinopharm Group Xinjiang Pharmaceutical Co., Ltd.
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Founded in:
1984-08-01 -
Address:
No. 21, Shaping West Street, Industrial Park, Urumqi Economic and Technological Development Zone (Touhunhe District), Xinjiang (China (Xinjiang) Pilot Free Trade Zone) -
Tax NO.:
9165010022866273X3 -
Registered Funds:
90.964 million yuan -
Website:
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Email: