Penicillin Potassium for Injection

Penicillin has good antibacterial effect on hemolytic streptococci and other streptococci, Streptococcus pneumoniae and non-penicillinase-producing staphylococci. It has moderate antibacterial effect on enterococci. Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus candida, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. This product also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis, and other Gram-negative aerobic or facultative anaerobic bacteria are less sensitive to this product. This product has good antibacterial effect on Clostridium, Peptostreptococcus anaerobic bacteria and melanin-producing Bacteroides, but has poor antibacterial effect on Bacteroides fragilis. Penicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

Penicillin Potassium

This product is white or crystalline powder.

Penicillin is suitable for various infections caused by sensitive bacteria, such as abscesses, bacteremia, pneumonia and endocarditis. Among them, penicillin is the first choice for the following infections. 1. Hemolytic streptococcal infections, such as pharyngitis, tonsillitis, scarlet fever, erysipelas, cellulitis and puerperal fever. 2. Pneumococcal infections such as pneumonia, otitis media, meningitis and bacteremia. 3. Non-penicillinase-producing staphylococcal infections. 4. Anthrax. 5. Clostridium infections such as tetanus and gas gangrene. 6. Syphilis (including congenital syphilis). 7. Leptospirosis. 8. Relapsing fever. 9. Diphtheria. 10. Penicillin is combined with aminoglycosides to treat viridans streptococcal endocarditis. Penicillin can also be used to treat: 1. Epidemic cerebrospinal meningitis. 2. Actinomycosis. 3. Gonorrhea. 4. Fensen angina. 5. Lyme disease. 6. Rat-bite fever. 7. Listeria infection. 8. Many anaerobic infections except Bacteroides fragilis. Penicillin can be used to prevent infective endocarditis in patients with rheumatic heart disease or congenital heart disease before oral, dental, gastrointestinal or genitourinary tract surgery and procedures.

Penicillin is administered by intramuscular injection or intravenous drip. 1 Adults: intramuscular injection, 800,000 to 2 million units per day, divided into 3 to 4 doses; intravenous drip: 2 million to 20 million units per day, divided into 2 to 4 doses. 2 Children: intramuscular injection, 25,000 units/kg of body weight, once every 12 hours; intravenous drip: 50,000 to 200,000 units/kg of body weight per day, divided into 2 to 4 doses. 3 Newborns (full-term): 50,000 units/kg of body weight each time, intramuscular injection or intravenous drip; once every 12 hours in the first week after birth, once every 8 hours for those over one week old, and once every 6 hours for severe infection. 4 Premature infants: 30,000 units/kg of body weight each time, once every 12 hours in the first week after birth, once every 8 hours for those 2 to 4 weeks old; once every 6 hours thereafter. 5 Patients with impaired renal function: Patients with mild and moderate renal impairment do not need to reduce the regular dose, while patients with severe renal impairment should extend the dosing interval or adjust the dose. When the endogenous creatinine clearance rate is 10-50ml/min, the dosing interval is extended from 8 hours to 8-12 hours, or the dosing interval remains unchanged and the dose is reduced by 25%; when the endogenous creatinine clearance rate is less than 10ml/min, the dosing interval is extended to 12-18 hours, or each dose is reduced to 25%-50% of the normal dose and the dosing interval remains unchanged. 6 For intramuscular injection, 500,000 units of penicillin potassium are dissolved in 1ml of sterile water for injection. If it exceeds 500,000 units, 2ml of sterile water for injection should be added. Sodium chloride injection should not be used as a solvent; the administration rate during intravenous drip should not exceed 500,000 units per minute to avoid central nervous system toxicity.

1. Allergic reactions: Allergic reactions to penicillin are common, including various rashes such as urticaria, leukopenia, interstitial nephritis, asthma attacks, and serum sickness reactions; anaphylactic shock is rare. Once it occurs, it is necessary to rescue on the spot, keep the airway open, inhale oxygen, and use epinephrine, glucocorticoids and other treatment measures. 2. Toxic reactions: Rare, but when large doses of this product are administered by intravenous drip or intrathecal administration, convulsions, muscle cramps, coma, and severe mental symptoms (penicillin encephalopathy) may occur due to excessive drug concentrations in the cerebrospinal fluid. This reaction is more common in infants, the elderly, and patients with renal insufficiency. 3. Herxheimer's reaction and treatment contradictions: When penicillin is used to treat diseases such as syphilis and leptospirosis, symptoms may worsen due to the death of the pathogen.

It is contraindicated in patients with a history of allergy to penicillins or a positive penicillin skin test.

Precautions for children: Precautions for pregnancy and lactation: Animal reproduction tests have not found that this product causes fetal damage. However, strict controlled tests have not been conducted on pregnant women to exclude the adverse effects of this type of drug on the fetus, so pregnant women should only use this product when it is really necessary. A small amount of this product is secreted from breast milk, so lactating women should stop breastfeeding when taking the drug. Precautions for the elderly:

1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so it is not suitable to drip in the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion will cause turbidity. 5 This product and aminoglycoside antibiotics drip in the same bottle may lead to a decrease in the antibacterial activity of both, so it cannot be placed in the same container for administration.

Keep tightly closed in a cool, dark and dry place.

0.25g (400,000 units)

CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

• Founded in:

  1997-12-12

• Address:

  No. 88, Yangzi Road, Shijiazhuang Economic and Technological Development Zone, Hebei Province

• Tax NO.:

  91130100601908022F

• Registered Funds:

  678.5559 million yuan

• Website:

  Log in to view

• Email:

  Log in to view