Penicillin G potassium salt
-
Penicillin G potassium salt
structure -
-
CAS No:
113-98-4
-
Formula:
C16H17KN2O4S
-
Chemical Name:
Penicillin G potassium salt
-
Synonyms:
tabilin;PENICILLIN G K-SALT;PENICILLIN G POTASSIUM SALT;PENICILLIN G POTASSIUM;potassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;potassium benzylpenicillin;4-Thia-1-azabicyclo;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, [2S-(2alpha,5alpha,6beta)]-, monopotassium salt
- Categories:
-
CAS No:
Description
White powderChEBI: Organic potassium salt of benzylpenicillin.
Benzylpenicillin potassiumwas the first crystalline penicillin produced on an industrial scale , . It is produced in the pure state by the addition of phenylacetate to a culture of Penicillium chrysogenum. The crystalline benzylpenicillin potassium contains 1598 U/mg.
Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.
ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).
Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
Penicillin G potassium salt Basic Attributes
373.49
372.054596
3832841
204-038-0
TSCA listed
Needles from butanol (aq)
29411000
Characteristics
115
-0.14510
powder
214-217 C
294 ° (C=1, H2O)
Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
2-8°C
LD50 oral in rabbit: 5848mg/kg
Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes
D22 +285° (c = 0.748 in water)
pH (10g/L, 25℃) : 5.0～7.5
Sealed in dry,Store in freezer, under -20°C
Safety Information
NONH for all modes of transport
2
Xn,C,F
36/37-45-36/37/39-26-16-60-37-24-22
XH9700000
Xn,C,F
Ventilated, low temperature and dry
P280
42/43-34-11
Penicillin G potassium salt Use and Manufacturing
A series of experiments was carried out in which to 1000 ml of an activated- carbon-treated extract containing approximately 100, 000 Oxford Units Penicillin G per ml in n-butylacetate, a 50percent (w/w) solution of KTo 1000 ml of an activated-carbon-treated extract containing approximately 100, 000 Oxford Units Penicillin G per ml (1 Oxford Unit equals circa 0.6 microgram of penicillin G) in n-butylacetate, a 30percent (w/w) solution of K
An antibiotic substance produced by Penicillium sp. Antibacterial.
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE
Computed Properties
Molecular Weight:372.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:372.05460969
Monoisotopic Mass:372.05460969
Topological Polar Surface Area:115
Heavy Atom Count:24
Complexity:536
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Penicillin has good antibacterial effect on hemolytic streptococci and other streptococci, Streptococcus pneumoniae and non-penicillinase-producing staphylococci. It has moderate antibacterial effect on enterococci. Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus candida, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. This product also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis, and other Gram-negative aerobic or facultative anaerobic bacteria are less sensitive to this product. This product has good antibacterial effect on Clostridium, Peptostreptococcus anaerobic bacteria and melanin-producing Bacteroides, but has poor antibacterial effect on Bacteroides fragilis. Penicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.
Registered Holders
-
ACS DOBFAR SPA
Active![Italy]()
Italy
-
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.
Active![China]()
China
-
Jiangxi Dongfeng Pharmaceutical Co., Ltd.
Active![China]()
China
Recommended Suppliers of Penicillin G potassium salt
-
InquiryCAS No.: 113-98-4Grade: Pharmaceutical GradeContent: 99%
-
![China]()
CN
3 YRS
Business licensedTrader Supplier of Apigenin,PQQ,NMNHInquiryUnit Price: $10.4-11.44 /G FOBCAS No.: 113-98-4Grade: Chemical GradeContent: 99% -
![China]()
CN
9 YRS
Business licensed Certified factoryManufactory Supplier -
![China]()
CN
3 YRS
Business licensedTrader Supplier of olive leaf extract,ginger extract,ginseng extract,Black garlic extract,Echinacea purpurea extract,Horse Chestnut Extract,Pueraria extract,Andrographis Extract,citrus aurantium extract,quercetin,Rutin,chlorogenic acid,Curcumin,ApigeninInquiryCAS No.: 113-98-4Grade: Pharmaceutical GradeContent: 99.9% -
![China]()
CN
2 YRS
Business licensedTrader Supplier of Titanium dioxide,npk,pvc,sles,labsa,mdi,tdi,Ethylene glycol,p-xylene,mtbe,styrene,Ethyl alcohol,Anthracite (coke),Citric acid,carbinol,toluene,Acetic acid,Dichloroethane,PhenolInquiryCAS No.: 113-98-4Grade: Top ProductContent: 99%
Learn More Other Chemicals
-
Cytidine 2',3'-phosphoric acid potassium salt
20486-23-1
-
Benzoic acid, 4-hydroxy-, potassium salt (1:1)
16782-08-4
-
Ethanol, 2-phenoxy-, 1-(dihydrogen phosphate), potassium salt (1:2)
65379-23-9
-
1,6-Anthracenedisulfonic acid, 5-amino-8-bromo-9,10-dihydro-9,10-dioxo-, potassium salt (1:2) Formula
68109-92-2
-
Butanedioic acid, 2,3-dihydroxy-, potassium salt (1:2), (2R,3R)-rel- Formula
147-78-4
-
CYANINE 5 MONOFUNCTIONAL HEXANOIC ACID DYE, SUCCINIMIDYL ESTER, POTASSIUM SALT Formula
1358906-77-0
-
1-Decanol, 2-hexyl-, phosphate, potassium salt Structure
39373-89-2
-
Cyanine 3 Bisethyl Dye PotassiuM Salt Structure
474972-41-3
-
What is 2-Naphthalenesulfonic acid, 6-amino-5-[2-[5-[(3-chlorobenzoyl)amino]-2-sulfophenyl]diazenyl]-4-hydroxy-, potassium salt (1:2)
67875-06-3
-
What is Sulfurous acid, potassium silver(1+) salt (1:1:1)
67859-68-1