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Penicillin G potassium

Penicillin G potassium structure

CAS No:
113-98-4
Formula:
C16H18N2O4S.K
Chemical Name:
Penicillin G potassium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-,potassium salt (1:1);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-,monopotassium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2α,5α,6β)]-,monopotassium salt;Penicillin G,potassium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-,monopotassium salt;Benzylpenicillinic acid potassium salt;Benzylpenicillin potassium;Benzylpenicillin potassium salt;Eskacillin;Falapen;Hipercilina;Notaral;Penicillin G potassium;Pentids;Potassium benzylpenicillin;Potassium benzylpenicillinate;Potassium penicillin G;Tabilin;Potassium 2,2-dimethyl-6β-phenylacetamidopenam-3α-carboxylate;Forpen;Hylenta;Hyasorb;Cristapen;Monopen;Megacillin tablets;Scotcil;Potassium 6-(phenylacetamido)penicillanate;Novocillin vet.;Cosmopen;M-Cillin;Pentid;Crytapen;NSC 131815;Pfizerpen;55878-83-6
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

White powderChEBI: Organic potassium salt of benzylpenicillin.

Penicillin G potassium Basic Attributes

Molecular Weight：

372.48

Exact Mass：

372.054596

EC Number：

204-038-0

HScode：

29411000

Characteristics

PSA：

115

XLogP3：

-0.14510

Appearance：

powder

Melting Point：

214-217 °C (decomp)

Refractive Index：

294 ° (C=1, H2O)

Water Solubility：

soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.

Storage Conditions：

2-8°C

Toxicity：

Oral-rat LD50; 6700 mg/kg; Oral-Mouse LD50: 6257 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Specific rotation：

D22 +285° (c = 0.748 in water)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43-34-11

safety instructions：

36/37-45-36/37/39-26-16-60-37-24-22

RTECS Number：

XH9700000

Marks：

Xn,C,F

Storage features：

Ventilated, low temperature and dry

Precautionary statement(s)：

P280

Hazard Statements：

H317

Toxicity

Toxicity class：

practically nontoxic

Penicillin G potassium Use and Manufacturing

Methods of Manufacturing

A series of experiments was carried out in which to 1000 ml of an activated- carbon-treated extract containing approximately 100, 000 Oxford Units Penicillin G per ml in n-butylacetate, a 50percent (w/w) solution of KTo 1000 ml of an activated-carbon-treated extract containing approximately 100, 000 Oxford Units Penicillin G per ml (1 Oxford Unit equals circa 0.6 microgram of penicillin G) in n-butylacetate, a 30percent (w/w) solution of K

Uses

An antibiotic substance produced by Penicillium sp. Antibacterial.

Manufacturing Info：

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE

Computed Properties

Molecular Weight:372.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:372.05460969
Monoisotopic Mass:372.05460969
Topological Polar Surface Area:115
Heavy Atom Count:24
Complexity:536
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Butyl acetate

Glucose

Potassium carbonate

Ethanol

1-Butanol

Downstream Products

Cephalexin

Benzimidazole

Penicillin G procaine

6-Aminopenicillanic acid

Drug Function and Efficacy

Penicillin has good antibacterial effect on hemolytic streptococci and other streptococci, Streptococcus pneumoniae and non-penicillinase-producing staphylococci. It has moderate antibacterial effect on enterococci. Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus candida, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. This product also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis, and other Gram-negative aerobic or facultative anaerobic bacteria are less sensitive to this product. This product has good antibacterial effect on Clostridium, Peptostreptococcus anaerobic bacteria and melanin-producing Bacteroides, but has poor antibacterial effect on Bacteroides fragilis. Penicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Penicillin Potassium for Injection
Ingredients	The main ingredient of this product is penicillin potassium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	Calculated as C16H17KN2O4S 0.625g (1 million units)
Manufacturer	Shandong Erye Pharmaceutical Co., Ltd.

Penicillin Potassium for Injection
Ingredients	The main ingredient of this product is penicillin potassium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	Calculated as C16H17KN2O4S 0.5g (800,000 units)
Manufacturer	Harbin Pharmaceutical Group Co., Ltd. GENERAL Pharm. FACTORY

Penicillin Potassium for Injection
Ingredients	The main ingredient of this product is penicillin potassium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	0.5g (800,000 units)
Manufacturer	Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

ACS DOBFAR SPA

Italy
Active
CSPC Zhongnuo PHARMACEUTICAL(Shijiazhuang) Co., Ltd.

China
Active
Jiangxi Dongfeng Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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