Compound α-keto acid tablets

This product can provide essential amino acids and minimize the intake of amino nitrogen. Ketones or hydroxyamino acids do not contain amino groups themselves. They use the nitrogen of non-essential amino acids to convert into amino acids, thus reducing urea synthesis and the accumulation of uremic toxic products. Ketones or hydroxyamino acids do not cause ultrafiltration of the remaining renal units, and can improve renal hyperphosphatemia and secondary hyperparathyroidism, and improve renal osteodystrophy. This product can reduce nitrogen intake when combined with a low-protein diet, while avoiding adverse consequences caused by insufficient protein intake and malnutrition. Toxicology studies have shown that the toxicity is low. Chronic toxicology studies have shown that the minimum toxic dose for dogs is 1200 mg/day and for rats is 2700 mg/day. When these doses are adjusted to the dosage for humans (weight 70 kg), they are converted to 84 g/day for dogs and 189 g/day for rats. This product has no embryotoxicity.

The chemical name is: It is a compound preparation containing 1 hydroxyamino acid calcium, 4 ketoamino acid calcium and 5 amino acids. Its composition: racemic hydroxymethionine calcium 59mg, threonine 53mg, racemic ketoisoleucine calcium 67mg, ketoleucine calcium 101mg, ketophenylalanine calcium 68mg, ketovaline calcium 86mg, lysine acetate 105mg, tryptophan 23mg, histidine 38mg, tyrosine 30mg. Total calcium content/tablet 1.25mmol≈50mg Total nitrogen content/tablet 36mg.

This product is a yellow film-coated tablet, which becomes white after removing the film coating.

Combined with a low-protein diet, it can prevent and treat damage caused by protein metabolism disorders due to chronic renal insufficiency. It is usually used for patients with a glomerular filtration rate of less than 25 ml per minute. A low-protein diet requires an adult daily protein intake of 40 grams or less.

Oral administration. 1. Take 4 to 8 tablets 3 times a day, swallow the whole tablet during meals. Follow the doctor's advice if necessary. This dosage is calculated based on a 70kg adult body weight. 2. For patients with a glomerular filtration rate less than 25 ml per minute, this product can be taken long-term with a low-protein diet of no more than 40 grams per day (for adults).

Hypercalcemia may occur. If hypercalcemia occurs, it is recommended to reduce the intake of vitamin D. If hypercalcemia persists, reduce the dosage of this product and reduce the intake of other calcium-containing substances.

1. Hypercalcemia and amino acid metabolism disorders. 2. When patients with hereditary phenylketonuria use this product, they should be aware that this product contains phenylalanine.

Precautions for children: There is no data on the use of this product by children. Precautions for pregnancy and lactation: There is no experience of use by pregnant and lactating women. Precautions for the elderly: No special requirements.

1. When used with other calcium-containing drugs, it can increase blood calcium levels. 2. When patients with uremia take this product for treatment, if aluminum hydroxide drugs are used at the same time, the dosage of aluminum hydroxide should be reduced. Pay attention to the decrease in blood phosphorus levels. 3. In order not to affect drug absorption, drugs that combine with calcium to form insoluble complexes (such as tetracycline, quinolones such as ciprofloxacin and norfloxacin, iron preparations, fluoride and drugs containing estramustine, etc.) should not be taken at the same time as the prescription. The interval between taking these drugs and the prescription is at least 2 hours. 4. Increased blood calcium can increase the sensitivity of cardiac glycoside drugs, and therefore increase the risk of arrhythmias.

Store in a dry place below 25℃.

0.63g

36 months.

Beijing Fresenius Kabi Pharmaceutical Co., Ltd.

• Founded in:

  1994-07-18

• Address:

  No. 57, Huatuo Road, Daxing Biomedicine Industry Base, Zhongguancun Science Park, Daxing District, Beijing

• Tax NO.:

  911100006000562780

• Registered Funds:

  $20.6 million

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