Bifendate Capsules
Function and Efficacy
This product is an intermediate in the synthesis of Schisandra chinensis propyl. Oral administration of 150-200 mg/kg of this product to mice can reduce liver damage caused by carbon tetrafluoride and the increase of alanine aminotransferase (ALT). It has an inhibitory effect on liver microsomal lipid peroxidation caused by carbon tetrachloride and the conversion of carbon tetrachloride into carbon monoxide, and reduces the consumption of reduced coenzyme II and oxygen in the process of carbon tetrachloride metabolism, thereby protecting the structure and function of liver cell biomembrane. This product can also reduce the increase of liver ALT induced by prednisone and promote liver regeneration in mice with partial hepatectomy. The enzyme-lowering effect of this product does not directly inhibit the activity of serum and liver ALT, nor does it accelerate the inactivation of ALT in the blood, which may be a reflection of the reduction of liver tissue damage. This product has a significant induction effect on the activity of cytochrome P450 enzymes, thereby enhancing the detoxification ability of carbon tetrachloride and certain carcinogens. It has an effect on improving protein metabolism in some hepatitis patients, increasing albumin and reducing globulin. It has no negative conversion effect on HbsAg and HbeAg, and cannot shrink the enlarged liver and spleen.
Ingredients
The main component of this product is biphenyl diester, and its chemical name is: 4,4-dimethoxy-5,6,5',6'-dimethoxy-2,,2'-dicarboxylic acid methyl biphenyl. Chemical structure: Molecular formula: C20H18O10 Molecular weight: 418.36
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| BifendateIngredients |
Reduce liver damage and alanine aminotransferase (ALT) elevation caused by carbon tetrafluoride; inhibit liver microsomal lipid peroxidation caused by carbon tetrachloride, carbon tetrachloride metabolism into carbon monoxide, and reduce the consumption of reduced coenzyme II and oxygen in the process of carbon tetrachloride metabolism, thereby protecting the structure and function of liver cell biomembrane; reduce prednisone-induced liver ALT elevation; promote liver regeneration in mice with partial hepatectomy; have a significant induction effect on cytochrome P450 enzyme activity, thereby enhancing the detoxification ability of carbon tetrachloride and certain carcinogens; improve protein metabolism in some hepatitis patients, increase albumin and reduce globulin. It has no negative conversion effect on HbsAg and HbeAg, and cannot shrink enlarged liver and spleen. More |
73536-69-3 | 12 |
Appearance
This product is white tablets.
Indication
It is used for patients with chronic persistent hepatitis accompanied by abnormally elevated alanine aminotransferase (ALT); it can also be used for elevated ALT caused by chemical drugs.
Usage and Dosage
Oral administration: 25-50 mg (1-2 tablets) at a time, 3 times a day.
Adverse Reactions
In some cases, mild nausea and occasional rash may occur after taking the drug.
Precautions
1. Those who are allergic to this product are prohibited from using it. 2. Those with liver cirrhosis are prohibited from using it. 3. Pregnant and lactating women are prohibited from using it.
Special Population Medication
Precautions for children: Reduce the dosage for children. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients should use this product with caution.
Drug Interactions
Not yet clear.
Storage
Keep away from light and store in sealed container.
Packaging Specification
25 mg
Validity Period
Tentative 24 months
Manufacturer
Shenyang Kangzhi Pharmaceutical Co., Ltd.
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Founded in:
1979-11-08 -
Address:
No. 7A1, Kaifa Road, Shenyang Economic and Technological Development Zone -
Tax NO.:
912101001179954513 -
Registered Funds:
12.678899 yuan -
Email: