Trimebutine Maleate Tablets

1 Gastric motility regulation effect: Adding 10-5g/ml of this product to the isolated guinea pig gastric vestibular circular muscle specimen can reduce the amplitude of its spontaneous movement. In addition, it can also increase the frequency and amplitude of the irregular weak movement of the same specimen at 28°C, making it tend to regular rhythmic contraction. When 3mg/kg of this product is intravenously injected into anesthetized dogs with cut thoracic vagus nerves, the irregular movement of the stomach can be regularized. For patients with digestive system diseases, intravenous injection of 1mg/kg of this product can inhibit the movement of hyperkinetic muscle groups, and at the same time, it can also be found that it can enhance the movement of hypokinetic muscle groups; 2. Inducing effect on propulsive movement of the digestive system. After 4-6mg/kg of the drug was administered in the human jejunum, it was found that it could induce physiological propulsive movement of the digestive system in adults; 3. Improvement of gastric emptying function. For patients with chronic gastritis who often have unexplained upper abdominal digestive tract discomfort, oral administration of 200mg of this product can improve the weakening of gastric emptying function, and at the same time, it can also inhibit hyperactivity of gastric emptying function. 4. Intestinal movement regulation effect. In the experiment of isolated guinea pig colon specimens, at 10-5g/ml, it has the effect of increasing tension for low muscle tension (under low load), and has the effect of reducing tension and reducing amplitude for hyperkinetic muscle tension (under high load). Hyperkinetic movement of the large intestine caused by psychological fatigue load of allergic enteritis syndrome can be inhibited by taking 300mg of this product. For patients with hypermotility caused by neostigmine load, 50 mg intravenous administration can inhibit the movement of the ileum, ascending colon, and sigmoid colon to the pre-load level; 5. Regulation of lower esophageal sphincter pressure (LESP) Experiments on lower esophageal sphincter pressure in anesthetized dogs showed that 0.6 mg/kg intravenous administration can reduce the increase in internal pressure caused by tetragastrin load, and can also restore the decrease in internal pressure caused by secretin; 6. Direct effect on digestive tract smooth muscle Experiments on isolated guinea pig gastric vestibule circular muscle specimens found that even in the presence of atropine, phentolamine, propranolol, and tetrodotoxin, this product still has a direct effect on digestive tract smooth muscle. Experiments on isolated guinea pig ileum found that this product can non-competitively inhibit the contraction caused by acetylcholine. It was also found that after the vagus nerve in the chest of anesthetized dogs was removed, it still had a direct effect on the gastrointestinal motility; 7 The peripheral antiemetic effect of the experiment on dogs found that although the inhibitory effect on apomorphine-induced vomiting was weak, for vomiting induced by copper sulfate, after intravenous injection of 3mg/kg or oral administration of 60mg/kg of this product, it can significantly prolong the time required to induce vomiting.

trimebutinemaleate

This product should be white or off-white tablets.

(1) Improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, borborygmus, abdominal pain, diarrhea and constipation caused by gastrointestinal motility disorders. (2) Irritable bowel syndrome.

Oral administration, 100-200 mg each time, 3 times a day. Increase or decrease the dose appropriately according to age and symptoms, or follow the doctor's advice.

Occasionally, there may be thirst, numbness in the mouth, abdominal borborygmi, abdominal distension, constipation, tachycardia, drowsiness, dizziness, headache, rash, increased aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), etc., with an incidence of about 0.4%.

It is contraindicated in patients allergic to trimebutine maleate.

Precautions for children: Use with caution in children. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Elderly people usually have weaker physiological functions and should pay attention to reducing the dosage.

Co-administration of proton pump inhibitors accelerates ulcer healing.

Keep away from light and store in a sealed container.

0.2g

24 months

Hainan Poly Pharm. Co., Ltd.

• Founded in:

  1992-07-14

• Address:

  Guilinyang Economic Development Zone, Meilan District, Haikou City

• Tax NO.:

  91460000620000247L

• Registered Funds:

  448.350021 million yuan

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