Trimebutine Maleate Tablets

1 Effect on digestive tract motility: 1) Gastric motility regulation effect Adding 10-5g/ml of this drug to the isolated guinea pig gastric vestibule circular muscle specimen can reduce the amplitude of its autonomic movement. In addition: it can also increase the frequency and amplitude of irregular weak movements of the same specimen at 28°C, making it tend to regular rhythmic contraction. When 3mg/kg of this drug is intravenously injected into anesthetized dogs with cut thoracic vagus nerves, the irregular movement of the stomach can be regularized. For the gastric pyloric movement of patients with digestive system diseases, intravenous injection of 1mg/kg was found to inhibit the movement of hyperkinetic muscle groups, and at the same time, it was also found to enhance the movement of hypokinetic muscle groups. 2) Effect on the induction of propulsive movement of the digestive system After 4-6mg/kg of the drug was administered in the human jejunum, it was found that it could induce physiological propulsive movement of the digestive tract in the adult digestive system. 3) Improvement of gastric emptying function. For patients with chronic gastritis who often have unexplained upper abdominal digestive tract discomfort, oral administration of 200 mg of this drug can improve the weakening of gastric emptying function and inhibit the hyperactivity of gastric emptying function. 4) Intestinal motility regulation. 5) In the experiment of isolated guinea pig colon specimens, at 10-5g/ml, it has the effect of increasing tension for low muscle tension (under low load), and has the effect of reducing tension and amplitude for hyperactivity of muscle tension (under high load). Hyperactivity of large intestine caused by psychological fatigue load of allergic enteritis syndrome. Taking 300 mg of this agent can be inhibited. For patients with hyperactivity caused by neostigmine load, intravenous administration of 50 mg can inhibit the movement of ileum, ascending colon and sigmoid colon to the pre-load level. 6) Regulation of lower esophageal sphincter pressure (LESP) Experiments on lower esophageal sphincter pressure in anesthetized dogs showed that intravenous administration of 0.6 mg/kg can reduce the increase in internal pressure caused by tetragastrin load, and can also restore the decrease in internal pressure caused by secretin. 7) Direct effect on digestive tract smooth muscle Experiments on isolated guinea pig gastric vestibular circular muscle specimens found that even in the presence of atropine, phentolamine, propranolol and tetrodotoxin, this drug still has a direct effect on digestive tract smooth muscle. Experiments on isolated guinea pig ileum found that this agent can non-competitively inhibit the contraction caused by acetylcholine. It was also found that after the vagus nerve in the chest of anesthetized dogs was removed, it still had a direct effect on digestive tract motility. 2 Peripheral antiemetic effect Experiments on dogs found that although its inhibitory effect on apomorphine-induced vomiting was weak, it could significantly prolong the time required to induce vomiting induced by copper sulfate after intravenous injection of 3 mg/kg or oral administration of 60 mg/kg.

Trimebutine maleate (C22H29NO5C4H4O4).

This product should be white or off-white tablets.

1. Improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, borborygmus, abdominal pain, diarrhea and constipation caused by gastrointestinal motility disorders. 2. Irritable bowel syndrome.

For adults, take orally, 0.1-0.2 g each time, 3 times a day. The dosage can be appropriately increased or decreased according to age and symptoms, or as directed by a doctor.

Occasionally, there may be thirst, numbness in the mouth, abdominal borborygmi, abdominal distension, constipation, tachycardia, drowsiness, dizziness, headache, rash, increased aspartate aminotransferase (GOT) and alanine aminotransferase (GPT), etc., with an incidence of about 0.4%.

It is contraindicated in patients allergic to trimebutine maleate.

Precautions for children: This product is not recommended. Precautions for pregnancy and lactation: Use with caution. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference literature.

Not yet clear.

Keep away from light and store in a sealed container.

0.1g

24 months

Hainan Poly Pharm. Co., Ltd.

• Founded in:

  1992-07-14

• Address:

  Guilinyang Economic Development Zone, Meilan District, Haikou City

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