Compound Cefaclor Capsules

This product is an antibacterial and expectorant. Cefaclor: It is relatively stable against beta-lactamase produced by Staphylococcus aureus, and therefore has a strong antibacterial effect on Gram-positive bacteria; its activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococci, grass-green streptococci and Staphylococcus epidermidis is the same as that of cefoperaxillin, and its antibacterial effect against non-enzyme-producing Staphylococcus aureus and pneumococci is 2 to 4 times stronger than that of cefoperaxillin. Cefaclor is more active than cefoperaxillin against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, and is similar to cefoperaxillin. Cefaclor is more active than cefoperaxillin against Proteus mirabilis, Salmonella and Shigella. 2.9 to 8 mg/L of cefaclor can inhibit all influenza bacilli, including ampicillin-resistant strains. Moraxella catarrhalis and gonococci are sensitive to this product. Indole-positive Proteus, Serratia, Acinetobacter and Pseudomonas aeruginosa are all resistant to cefaclor. Bromhexine hydrochloride: It has a strong effect of dissolving mucus and can break down the polysaccharide cellulose in sputum and dilute the sputum. It inhibits the synthesis of glycoproteins by goblet cells and mucous glands to reduce sialic acid in sputum, reduce sputum viscosity, and facilitate discharge.

Cefaclor, Bromohexine

This product is a capsule, and the contents are off-white or slightly yellow powder.

This product is mainly used to treat mild and moderate respiratory tract infections caused by bacteria; acute and chronic bronchitis; lung infections or sinusitis, etc.

The usual oral dose for adults is 1 tablet, 3 times a day. The dose can be doubled for patients with severe infection, but the daily dose should not exceed 4g. The daily oral dose for children is 20mg/kg, 3 times a day. In severe cases, 40mg/kg can be given per day, but the daily dose should not exceed 1g.

Gastrointestinal: Occasionally nausea, stomach discomfort, diarrhea, etc. Allergic reactions: urticaria, rash, eosinophilia, vulvar itching, etc. Others: Slight increase in BUN and Cr, proteinuria, cystic urine, etc.

It is contraindicated for those who are allergic to cephalosporins and those who are coughing up blood.

Precautions for children: The safety and effectiveness of the drug for children has not yet been determined. Precautions for pregnancy and lactation: Although there is no data to prove the harm of taking this drug when pregnant or lactating women take it, since the drug enters breast milk, lactating women should not take this product; pregnant women should use it with caution. Precautions for the elderly: Elderly patients should adjust the dosage or medication interval according to their renal function under the guidance of a doctor.

⑴ Cefaclor is contraindicated with the following drugs: amikacin sulfate, gentamicin, kanamycin, tobramycin, neomycin, chlortetracycline hydrochloride, tetracycline hydrochloride, oxytetracycline hydrochloride, colistin sodium mesylate, polymyxin B sulfate, erythromycin glucoheptonate, erythromycin lactobionate, lincomycin, sulfamethoxazole, aminophylline, soluble barbiturates, calcium chloride, calcium glucoheptonate, diphenhydramine hydrochloride and other antihistamines, lidocaine, norepinephrine, metaraminol, methylphenidate, succinylcholine, etc. It may also be contraindicated with the following drugs: epimycin, methicillin, hydrocortisone sodium succinate, phenytoin sodium, prochlorperazine, vitamin B group and vitamin C, hydrolyzed protein. ⑵ Strong diuretics such as furosemide, ethacrynic acid, bumetanide, antineoplastic drugs such as carmustine, streptozotocin, and aminoglycoside antibiotics used together with cefaclor may increase nephrotoxicity. ⑶ Cefaclor combined with rifampicin or vancomycin in vitro can enhance the effect on methicillin-resistant Staphylococcus epidermidis. ⑷ Clavulanic acid (1 or 5 mu; g/ml) can reduce the MICS of cefaclor against 55 penicillin-resistant Bacillus in vitro. It has no effect on the MICS of fusidiformes and multi-branched fusidiformes. Clavulanic acid can also enhance the antibacterial activity of cefaclor against cefaclor-resistant Pneumococcus. ⑸ Bromohexine hydrochloride combined with tetracycline antibiotics can increase the antibacterial efficacy.

Keep away from light, tightly sealed, and stored in a cool, dark and dry place.

Each tablet contains 250mg of cefaclor and 8mg of bromhexine

24 months

Kinhoo Pharmaceutical Co., Ltd.

• Founded in:

  2005-04-18

• Address:

  Zhuhai Golden Coast Bio-Industrial Zone

• Tax NO.:

  914404007740042759

• Registered Funds:

  65.6 million yuan

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