Propiverine Hydrochloride Tablets

1. Inhibition of bladder micturition movement in vivo: (1) Increase bladder capacity. Cystometritis measurement showed that this drug can increase the maximum bladder capacity of anesthetized rats and dogs, as well as the maximum bladder capacity and effective bladder capacity of decapitated dogs, but no significant increase in residual urine volume was observed; (2) Inhibition of micturition movement. This drug can reduce the number of rhythmic contractions (micturition movements) when the bladder is filled in anesthetized rats and dogs; (3) Inhibition of bladder contraction caused by electrical stimulation. Regardless of whether the pelvic nerve is cut, this drug can reduce the contraction force of the bladder caused by electrical stimulation of the dog's pelvic nerve. 2. Effect on isolated bladder. It can inhibit the contraction of bladder smooth muscle caused by acetylcholine, calcium chloride (rats, dogs, guinea pigs), and electrical stimulation (rats, dogs, rabbits) in a dose-related manner; 3. Mechanism of action. It can inhibit the contraction of acetylcholine and calcium chloride on isolated bladder, has affinity for myosin receptors, and can inhibit the contraction caused by electrical stimulation that atropine cannot inhibit. It can also inhibit the bladder contraction caused by stimulation of the cut pelvic nerve endings, indicating that this drug can directly act on bladder smooth muscle. In addition, the main metabolite of this drug, 1-methyl-4-piperidinyl-diphenylpropoxyacetic acid-N-oxide (N-oxide of this drug, hereinafter referred to as M-1) directly acts on smooth muscle, and 1-methyl-4-piperidinyl-benzoic acid-N-oxide (depropylated derivative of M-1, hereinafter referred to as M-2) has an anticholinergic effect. Therefore, this drug can directly act on smooth muscle and has an anticholinergic effect, but it is mainly because it directly inhibits smooth muscle and inhibits urination movement.

The main ingredient of this product is propiverine hydrochloride. Its chemical name is: 1-methyl]-4-piperidinyl diphenoxy propoxyacetate hydrochloride. Structural formula: Molecular formula: C23H29NO3HCl Molecular weight: 403.95

This product is white tablets.

This product is effective for methemoglobinemia caused by chemicals such as nitrite, nitrate, aniline, nitrobenzene, trinitrotoluene, benzoquinone, phenylhydrazine, etc. and drugs containing or producing aromatic amines (acetanilide, acetaminophen, phenacetin, benzocaine, etc.). It is less effective for methemoglobinemia caused by congenital reduced diphosphate pyridine nucleoside methemoglobin reductase deficiency. It is ineffective for abnormal hemoglobin M accompanied by methemoglobinemia. It can temporarily delay the toxicity of acute cyanide poisoning.

Intravenous injection: 1-2 mg/kg of body weight for nitrite poisoning, 5-10 mg/kg of body weight for cyanide poisoning, and the maximum dose is 20 mg/kg.

Intravenous injection of this product too quickly can cause dizziness, nausea, vomiting, chest tightness, abdominal pain, and excessive dosage. In addition to the aggravation of the above symptoms, headaches, lowered blood pressure, increased heart rate with arrhythmia, profuse sweating and impaired consciousness may also occur. After taking the drug, the urine will be blue and there may be stinging pain in the urethra during urination.

This product cannot be injected subcutaneously, intramuscularly or intrathecally, the former causes necrosis, and the latter causes paralysis. Excessive doses of this product in patients with 6-phosphate-glucose dehydrogenase deficiency and children may cause hemolysis. It should be used with caution in patients with renal insufficiency. This product is a 1% solution, which needs to be diluted with 40ml of 25% glucose injection and slowly injected intravenously (injection completed in 10 minutes). For methemoglobin leukemia caused by chemicals and drugs, if the cyanosis of the skin and mucous membranes does not subside within 30 to 60 minutes, the drug can be repeated. For methemoglobinemia caused by congenital reduced diphosphate pyridine nucleoside methemoglobin reductase deficiency, take 300mg orally and a large dose of vitamin C daily.

Precautions for children: Overdose of this product in children may cause hemolysis. Precautions for pregnancy and lactation: The effectiveness and safety of this product for pregnant women have not been established; animal experiments have shown that this product can be detected in breast milk, so lactating women should stop breastfeeding when using this product.

The mechanism of action is that it can inhibit the contraction of acetylcholine and calcium chloride on the isolated bladder, has affinity for myosin receptors, and can inhibit the contraction caused by electrical stimulation that atropine cannot inhibit. It can also inhibit the bladder contraction caused by stimulating the cut pelvic nerve endings, indicating that this drug can directly act on the bladder smooth muscle.

Keep away from light and store in a sealed container.

10mg

24 months

Kangmei Pharmaceutical Co., Ltd.

• Founded in:

  1997-06-18

• Address:

  East side of Jieshen Road, Liusha, Puning City, Guangdong Province

• Tax NO.:

  91445200231131526C

• Registered Funds:

  13,863,866,690 yuan

• Website:

  Log in to view

• Email:

  Log in to view