Ranitidine Hydrochloride Capsules

Ranitidine has the effect of competitively blocking the binding of histamine to H2 receptors. Its effect of inhibiting gastric acid is 5 to 12 times stronger than that of cimetidine. Therefore, it is a potent H2 receptor blocker. Toxicology: The oral LD50 of mice is 1440 to 1750 mg/kg. The maximum non-toxic dose per day for 5 consecutive weeks is 500 mg/kg for rats (male), 250 mg/kg for rats (female), and 40 mg/kg for dogs. The maximum non-toxic dose per day for 26 consecutive weeks is 100 mg/kg for rats and 40 mg/kg for dogs. Mice were orally administered 100 to 200 mg/kg for 114 weeks, and rats were orally administered 100 to 2000 mg/kg for 129 weeks, and no carcinogenic effect was observed.

Ranitidine hydrochloride.

This product is a capsule, and its contents are off-white or light yellow powder.

Used to treat duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome and other high gastric acid secretion diseases.

(1) Oral administration: 150 mg (1 tablet at a time), twice a day, or 300 mg (2 tablets at a time), once before bedtime. (2) Maintenance treatment: Oral administration: 150 mg (1 tablet at a time), once every night. (3) For patients with severe renal disease, the half-life of ranitidine is prolonged, and the dose should be reduced to 75 mg (half a tablet at a time), twice a day. (4) For the treatment of Zollinger-Ellison syndrome, a large dose of 600-1200 mg per day (4-8 tablets per day) is recommended.

(1) Common symptoms include nausea, rash, constipation, fatigue, headache, dizziness, etc. (2) Compared with cimetidine, the adverse effects of damage to kidney function, gonadal function and central nervous system are milder. (3) A small number of patients suffered mild liver damage after taking the drug, and the symptoms disappeared after stopping the drug, and liver function returned to normal. It was suspected that it might be a drug allergic reaction and had nothing to do with the dosage of the drug. (4) Long-term use can continuously reduce the acidity of gastric juice, which is conducive to the reproduction of bacteria in the stomach, thereby reducing nitrates in food to nitrites and forming N-nitroso compounds.

It is contraindicated for those who are allergic to this product.

Precautions for children: Children under 8 years old are prohibited. Precautions for pregnancy and lactation: Precautions for pregnant and lactating women. Precautions for the elderly: The liver and kidney functions of the elderly are reduced. To ensure the safety of medication, the dosage should be adjusted.

1. When used with procainamide, the clearance rate of procainamide may be reduced. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.

Keep away from light, sealed and stored in a dry place.

0.15g (calculated as C13H22N4O3S)

24 months

Kangmei Pharmaceutical Co., Ltd.

• Founded in:

  1997-06-18

• Address:

  East side of Jieshen Road, Liusha, Puning City, Guangdong Province

• Tax NO.:

  91445200231131526C

• Registered Funds:

  13,863,866,690 yuan

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