Compound Captopril Tablets

This product is a competitive angiotensin converting enzyme inhibitor, which prevents angiotensin I from converting into angiotensin II, thereby reducing peripheral vascular resistance and reducing water and sodium retention by inhibiting aldosterone secretion. This product can also dilate peripheral blood vessels by interfering with the degradation of bradykinin. For patients with heart failure, this product can also reduce pulmonary capillary wedge pressure and pulmonary vascular resistance, increase cardiac output and exercise tolerance time. This product can be secreted through breast milk and can pass through the placenta.

Captopril, hydrochlorothiazide, etc.

This product is white or off-white tablets

1. Hypertension: it can be used alone or in combination with other antihypertensive drugs. 2. Heart failure: it can be used alone or in combination with cardiotonic and diuretic drugs.

It depends on the condition or individual differences. This product should be taken under the guidance or supervision of a physician. The dosage must follow the principle of individualization and be adjusted according to the efficacy. 1. Common dosage for adults: (1) For hypertension, take 12.5 mg orally once, 2-3 times a day. Increase to 50 mg 2-3 times a day within 1-2 weeks as needed. If the efficacy is still unsatisfactory, other antihypertensive drugs can be added. (2) For heart failure, start with 12.5 mg orally once, 2-3 times a day. If necessary, gradually increase to 50 mg 2-3 times a day. If further increase is needed, observe the efficacy for 2 weeks before considering it. For patients who have recently taken a large amount of diuretics, are in hyponatremia/hypovolemia, and have normal or low blood pressure, the initial dose should be 6.25 mg 3 times a day, and then gradually increase to the common dose through testing. 2. Common dosage for children: For lowering blood pressure and treating heart failure, start with 0.3 mg/kg body weight, 3 times a day. If necessary, increase the dosage by 0.3 mg/kg every 8-24 hours to obtain the lowest effective dose.

1. The more common ones are: (1) Rash, which may be accompanied by itching and fever. It often occurs within 4 weeks of treatment and is maculopapular or urticaria. It disappears after reducing the dose, stopping the drug or taking antihistamines. 7%-10% are accompanied by eosinophilia or positive antinuclear antibodies. (2) Palpitations, tachycardia, chest pain. (3) Cough. (4) Dilated taste. 2. Less common ones are: (5) Proteinuria, which often occurs within 8 months of the start of treatment. One quarter of them will develop nephrotic syndrome, but proteinuria will gradually decrease within 6 months and the course of treatment will not be affected. (6) Dizziness, headache, and syncope. It is caused by hypotension, especially when there is a lack of sodium or blood volume. (7) Angioedema, seen on the face, hands and feet. (8) Rapid and irregular heart rate. (9) Facial flushing or pallor. 3. Rare symptoms include: leukocytopenia and granulocytopenia, fever, chills. Leukocytopenia is dose-related and occurs 3-12 weeks after the start of treatment, with the most significant symptoms at 10-30 days, and lasts for 2 weeks after stopping the drug.

Patients who are allergic to this product or other angiotensin-converting enzyme inhibitors are contraindicated.

Precautions for children: 1. It has been reported that this product can cause excessive and persistent decrease in blood pressure in infants, accompanied by oliguria and convulsions, so the use of this product is limited to those who are ineffective in other antihypertensive treatments. 2. Hydrochlorothiazide can increase blood bilirubin, so it should be used with caution in infants with jaundice. Precautions for pregnancy and lactation: 1. All drugs in this product can pass through the placental barrier. Absorption of angiotensin-converting enzyme inhibitors by pregnant women can affect fetal development and even cause fetal death, so pregnant women are prohibited from using it. 2. All drugs in this product can be excreted into breast milk, among which the concentration of captopril is about 1% of the maternal blood drug concentration, so lactating women must weigh the pros and cons. Precautions for the elderly: The elderly are more sensitive to antihypertensive effects and are more likely to have electrolyte disorders and renal damage, so the dosage of this product should be reduced as appropriate.

When used with diuretics, the antihypertensive effect is enhanced, but severe hypotension should be avoided. Therefore, those who originally used diuretics should stop taking them or reduce the dosage. This product is used at a small dose at the beginning and the dosage should be adjusted gradually. 1. When used with other vasodilators, it may cause hypotension. If it is suitable for use, it should be started with a small dose. 2. When used with potassium-retaining drugs such as spironolactone, triamterene, and amiloride, it may cause hyperkalemia. 3. When used with endogenous prostaglandin synthesis inhibitors such as indomethacin, the antihypertensive effect of this product will be weakened. 4. When used with other antihypertensive drugs, the antihypertensive effect is enhanced; it has an additive effect with drugs that cause renin release or affect sympathetic activity; it has a less than additive effect with szligand blockers.

Keep in a dark place, sealed and dry place below 30℃

Each tablet contains 10 mg of captopril and 6 mg of hydrochlorothiazide

24 months

Hangzhou Wanbang Tiancheng Pharmaceutical Co., Ltd.

• Founded in:

  2015-04-15

• Address:

  No. 1 Chunjiang Road, Qiaonan District, Xiaoshan Economic and Technological Development Zone, Xiaoshan District

• Tax NO.:

  91330109328248034G

• Registered Funds:

  10 million yuan

• Email:

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