Cilnidipine Tablets

This product is a lipophilic dihydropyridine calcium antagonist that can bind to the dihydropyridine site of the L-type calcium channel on the vascular smooth muscle cell membrane, inhibiting the transmembrane influx of Ca2 through the L-type calcium channel, thereby relaxing and dilating the vascular smooth muscle and playing a hypotensive role. It can also inhibit the release of norepinephrine from sympathetic nerve endings and sympathetic nerve activity by inhibiting the transmembrane influx of Ca2 through the N-type calcium channel on the sympathetic nerve cell membrane.

Cilnidipine.

This product is light yellow tablet.

Used for the treatment of patients with hypertension.

The initial dose for adults is 5 mg (one tablet each time), once a day, after breakfast. Depending on the patient's clinical response, the dose can be increased to a maximum of 10 mg (two tablets each time), once a day, after breakfast.

Urinary system: frequent urination, increased uric acid, creatine, uric acid nitrogen, positive urine protein, positive urine sediment; nervous system: headache, dizziness, shoulder muscle stiffness, drowsiness, insomnia, hand tremor, forgetfulness; circulatory system: flushing, palpitations, hot flashes, abnormal electrocardiogram (ST segment depression, T wave reversal), hypotension, chest pain, chills, extrasystole, sexual dysfunction; digestive system: increased AST, ALT, y-GTP and other liver function abnormalities, vomiting, abdominal pain, thirst, constipation, abdominal distension; blood system: abnormal white blood cell count, neutrophil thrombocytopenia, red blood cells, hematocrit, eosinophils and lymphocytes abnormalities; allergies: drug rash, itching; others: edema, fatigue, increased serum cholesterol, abnormal serum K and P, dry eyes, fullness

Patients who are allergic to any ingredient in this product are contraindicated.

Precautions for children: There is no data on the use of this product in children, and it is not recommended for children. Precautions for pregnancy and lactation: Pregnant women are prohibited from using it (animal experiments show that it is toxic to the fetus and can cause miscarriage). Because this product can be secreted through breast milk, lactating women should avoid using it. If it cannot be avoided, breastfeeding should be stopped. Precautions for the elderly: Elderly patients cannot excessively reduce blood pressure, so when using it for elderly patients, start with a low dose (such as 5 mg) and administer it carefully after sufficient observation.

Combined medication: 1. Ephedra It is not recommended for patients to use this product while taking drugs containing ephedra. Ephedrine in ephedra can aggravate the symptoms of hypertension. 2. Hypericum There are no clinical reports of interactions between this product and hypericum. However, hypericum and this product have the same metabolic pathway. This product is metabolized by the CYP450 enzyme system, which is a substrate for P-glycoprotein drug transport. Hypericum can activate cytochrome P4503A4 and P-glycoprotein in the human body. In vitro tests have shown that extracts of hypericum can inhibit cytochrome P450 isoenzymes including P4503A4. Therefore, calcium ion antagonists that can be metabolized by cytochrome P4503A4 should be avoided in combination with hypericum. 3. Combination with other antihypertensive drugs This product may have an additive effect when used in combination with other antihypertensive drugs, which enhances the antihypertensive effect and may lead to excessive reduction in blood pressure. 4. Combination with digoxin Combination of digoxin and calcium antagonists may increase the blood concentration of digoxin and even produce symptoms of digoxin poisoning, such as nausea, vomiting, headache, visual abnormalities, arrhythmia, etc. Adjusting the dosage of digoxin or terminating the administration of calcium antagonists can improve the corresponding symptoms. The possible mechanism is that calcium antagonists can reduce the renal and extrarenal clearance of digoxin. 5. Combination with cimetidine There are reports that calcium antagonists and cimetidine have enhanced effects. It may be that cimetidine reduces liver blood flow, inhibits the enzyme metabolism of calcium antagonists in liver microsomes, and reduces gastric acid, thereby increasing the absorption of calcium antagonists. 6. Combination with rifampicin There are reports that calcium antagonists and rifampicin have weakened effects. It may be that rifampicin induces liver enzymes, thereby promoting the metabolism of calcium antagonists and increasing their clearance. 7. When used in combination with azo antifungal drugs (such as ketoconazole and itraconazole), the blood concentration of this product will increase. This may be due to the inhibition of CYP3A4 by azo antifungal drugs and the reduction of the metabolism of this product. 8. When used in combination with grape juice, certain ingredients in grape juice can inhibit CYP3A4 and reduce the metabolism of this product, thereby causing the blood concentration of this product to increase.

Keep sealed and away from light.

5 mg

24 months

Shanxi Zhendong Taisheng Pharmaceutical Co., Ltd.

• Founded in:

  1993-07-05

• Address:

  The First Pharmaceutical Park, Economic and Technological Development Zone, Datong City, Shanxi Province

• Tax NO.:

  91140200602165291J

• Registered Funds:

  395 million yuan

• Website:

  Log in to view

• Email:

  Log in to view