Amiloride Hydrochloride Tablets

This product is a potassium-sparing diuretic that acts on the distal tubules of the kidneys, blocks the sodium-potassium exchange mechanism, promotes the excretion of sodium and chloride, and reduces the secretion of potassium and hydrogen ions. Its action is independent of aldosterone. Its own natriuretic and antihypertensive activities are weakened, but it has a synergistic effect when used in combination with thiazide or loop diuretics.

Main ingredient: Amiloride hydrochloride

This product is light yellow tablet.

It is mainly used to treat edema diseases and can also be used as an adjuvant treatment for refractory hypokalemia.

Oral administration: 1 tablet at a time, once a day, or twice a day if necessary, 1 tablet each in the morning and evening, with food.

1. Hyperkalemia is common when used alone. 2. This drug may occasionally cause hyponatremia, hypercalcemia, and mild metabolic acidosis. 3. Gastrointestinal reactions may include dry mouth, nausea, vomiting, abdominal distension, and other adverse reactions. 4. Headache, dizziness, chest tightness, sexual dysfunction, and other adverse reactions may also be seen. 5. Allergic reactions are mainly manifested as: rash and even difficulty breathing.

It is contraindicated in patients with severe renal impairment or hyperkalemia.

1. Adrenocortical hormones, especially those with strong mineralocorticoid effects, and adrenocorticotropic hormone can weaken the diuretic effect of this drug and antagonize the potassium retention effect of this drug. 2. Estrogen can cause water and sodium retention, thereby weakening the diuretic effect of this drug. 3. Non-steroidal anti-inflammatory analgesics, especially indomethacin, can reduce the diuretic effect of this drug, and the renal toxicity increases when used in combination. 4. Sympathomimetic drugs reduce the antihypertensive effect of this drug. 5. Dopamine enhances the diuretic effect of this drug. 6. When used in combination with drugs that cause a decrease in blood pressure, both the diuretic and antihypertensive effects are enhanced. 7. When used in combination with the following drugs, the chance of hyperkalemia increases, such as potassium-containing drugs, stored blood (containing 30mmol/L of potassium, such as potassium up to 65mmol/L if stored for more than 10 days), angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists and cyclosporine A. 8. When used in combination with glucose insulin solution, alkali agents, and sodium-type potassium-lowering exchange resins, the chance of hyperkalemia decreases. 9 This drug prolongs the half-life of digoxin. 10 Metabolic acidosis is likely to occur when used in combination with ammonium chloride. 11 When used in combination with nephrotoxic drugs, nephrotoxicity increases. 12 Sodium carbenoxolone and licorice preparations have aldosterone-like effects and can reduce the diuretic effect of this drug.

Keep away from light and store in a sealed container.

2.5 mg

Jiangsu Disainuo Pharmaceutical Co., Ltd.

• Founded in:

  2006-10-11

• Address:

  No. 3, Kang'an Road, Liyang Economic Development Zone, Jiangsu Province

• Tax NO.:

  91320481792322090C

• Registered Funds:

  100 million yuan

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