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Chuanhuning injection

Function and Efficacy

Pharmacological experiments show that: 1. This product has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins, and the effect is rapid and can last for more than 4 hours; 2. This product can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; 3. This product can shorten the sleep latency of mice caused by sodium pentobarbital, prolong their sleep time, and can also enhance the subthreshold effect of sodium pentobarbital to induce sleep in mice. The experimental results indicate that this product has a significant sedative effect; 4. This product can significantly promote the adrenal cortex function of rats and increase the body's emergency response to pathogen infection; 5. Clinical etiological diagnosis experiments and tissue culture inactivation experiments have shown that this product has an inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type Ⅲ, type Ⅳ, enterosyncytial virus and respiratory syncytial virus (Rsv). Chuanhuning is of low toxicity and non-irritating nature, with an intravenous drip LD50 of 675 mg/kg plus 30 mg/kg.

Ingredients

The main ingredients and chemical names of this product are: The main ingredient is chuanhuning. Chemical name: 14-dehydroxy 11, 12-didehydroandrographolide-3, 19-disuccinic acid half ester monopotassium salt.

Name Description Content CAS NO. Manufacturer
14-deoxy-11,12-didehydroandrographolide 3,19-disuccinateIngredients

1. It has a strong antipyretic effect on rabbits with fever caused by bacterial endotoxins, and the effect is rapid and can last for more than 4 hours; 2. It can counteract the increased permeability of capillary walls caused by xylene or histamine, and has a significant antagonistic effect on adrenaline-induced acute pulmonary edema; 3. It can shorten the sleep latency of mice caused by sodium pentobarbital, prolong their sleep time, and strengthen the subthreshold effect of sodium pentobarbital to induce sleep in mice, indicating that this product has a significant sedative effect; 4. It can significantly promote the function of the adrenal cortex of rats and increase the body's emergency response to pathogen infection; 5. It has an inactivation effect on influenza virus type AⅠ, type AⅢ, pneumonia adenovirus (Adv) type III, type IV, enterosyncytial virus and respiratory syncytial virus (RSV).

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76958-99-1 8

Appearance

This product is an almost colorless to light yellow clear liquid.

Indication

This product has the effects of clearing heat, detoxifying and resisting viruses, and is mainly used for viral pneumonia and viral upper respiratory tract infection.

Usage and Dosage

Intramuscular injection: 40-80 mg per time for adults, 1-2 times a day, and children can reduce the dosage or follow the doctor's advice. Intravenous drip: 400-800 mg per day, diluted with an appropriate amount of sodium chloride injection twice and dripped, each time should not exceed 400 mg, and children can reduce the dosage or follow the doctor's advice

Adverse Reactions

Skin allergic reactions and diarrhea in children are common after intravenous infusion, and anaphylactic shock and liver damage have been reported occasionally.

Precautions

1. Those who are allergic to this product are prohibited from using this product. 2. Pregnant women are prohibited from using this product.

Special Population Medication

Precautions for children: There is no sufficient clinical data for children. Precautions for pregnancy and lactation: Use with caution in pregnant women. Precautions for the elderly: Not yet clear.

Drug Interactions

This product should not be used in combination with acidic or alkaline drugs or drugs containing sodium bisulfite or sodium metabisulfite as antioxidants.

Storage

Keep tightly closed in a cool, dry place.

Packaging Specification

2ml:40mg

Validity Period

18 months

Manufacturer

Zhengzhou Zhuofeng Pharmaceutical Co., Ltd.

  • Founded in:

    2008-10-27
  • Address:

    North side of Renmin East Road, Xinzheng City
  • Tax NO.:

    91410184170459631H
  • Registered Funds:

    10 million yuan
  • Website:

  • Email:

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