Podophyllotoxin tincture
Function and Efficacy
Podophyllotoxin is a plant extract and a cell division inhibitor in the metaphase of cell division. In vitro and in vivo tests have shown that this product has anti-tumor activity, can inhibit microtubule polymerization, inhibit nuclear mitosis, and stop it in the metaphase. This product is not easily absorbed orally and has serious toxic and side effects, so its systemic application is limited. In vitro efficacy tests for topical treatment of condyloma acuminatum have shown that this product can inhibit the incorporation of deoxynucleosides and DNA synthesis in cultured normal human skin keratinocytes and cervical cancer epithelial cells, hindering their division and proliferation. After external application of this product, it can inhibit the division and proliferation of epithelial cells with warty proliferation caused by human papillomavirus (HPV) infection, causing necrosis and shedding, thereby playing a role in treating condyloma acuminatum.
Ingredients
Podophyllotoxin.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| PodophyllotoxinIngredients |
Podophyllotoxin is a plant extract and a cell division inhibitor in the metaphase of cell division. It can inhibit microtubule polymerization and nuclear mitosis, causing it to stop in the metaphase. When used externally to treat condyloma acuminatum, it can inhibit the division and proliferation of epithelial cells in warty proliferation caused by human papillomavirus (HPV) infection, causing them to necrotize and fall off, thus playing a therapeutic role. More |
518-28-5 | 7 |
Appearance
This product is a colorless clear solution with an ethanol odor.
Indication
Genital warts on the external genitalia and perianal area of men and women.
Usage and Dosage
1. Before applying the medicine, clean the affected area with a disinfectant and astringent solution (such as potassium permanganate solution, etc.) and wipe it dry; 2. Use a special medicine swab to apply the liquid medicine to the wart, apply it all over the wart, no need to repeat and try to avoid the liquid medicine from contacting normal skin and mucous membranes; 3. The total amount of medicine should not exceed 1 ml. After applying the medicine, expose the affected area to let the liquid medicine dry; 4. Apply the medicine twice a day, once in the morning and once in the evening, for 3 consecutive days, and do not apply the liquid medicine for the next 4 days. This is a course of treatment. If there are still residual lesions, you can repeat a course of treatment, but no more than three courses of treatment. If there are still condyloma after three courses of treatment, the patient should seek medical attention for further examination.
Adverse Reactions
1. Most patients may experience varying degrees of burning or tingling sensations, as well as erythema, edema and erosion at the site of application after medication. 2. Erythema or superficial erosion may occur locally after shedding. These are common local reactions and there is no need to stop the medication. 3. Some patients may have severe local reactions. Anti-inflammatory and astringent cold compresses or creams, lotions and pastes may be used to treat them. Symptoms can be quickly and significantly alleviated. For those with severe local ulcers, edema and severe pain, treatment can be stopped if necessary. 4. A small number of patients did not experience any adverse reactions during treatment. 5. No systemic adverse reactions were observed with topical treatment.
Precautions
It is contraindicated for people who are allergic to this drug, pregnant women, lactating women, and those with unhealed wounds after surgery.
Special Population Medication
Precautions for children: There is currently a lack of experimental data on the use of drugs in children, and it is recommended that children should not use the drug. Precautions for pregnancy and lactation: It is forbidden for breastfeeding women. Precautions for the elderly:
Drug Interactions
Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Storage
Keep away from light, tightly sealed and stored below 30℃.
Packaging Specification
3 ml: 15 mg
Validity Period
24 months.
Manufacturer
Liaoning Huawei Pharmaceutical Co., Ltd.
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Founded in:
2000-04-08 -
Address:
No. 62, Zhongxing Street, Yi County -
Tax NO.:
91210727121061977Q -
Registered Funds:
14.76 million yuan -
Email: