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Podophyllotoxin tincture

Function and Efficacy

In vitro and in vivo tests have proven that this product has anti-tumor activity, can inhibit microtubule polymerization, inhibit cell nuclear mitosis, and stop it at mid-phase. In vitro efficacy tests for external use in the treatment of condyloma acuminatum have proven that this product can inhibit the incorporation of deoxynucleoside and DNA synthesis in cultured normal human skin keratinocytes and cervical cancer epithelial cells, hindering their division and proliferation. After external application of this product, it can inhibit the division and proliferation of epithelial cells with warty proliferation caused by human papillomavirus (HPV) infection, causing them to necrotize and fall off, thereby playing a role in treating condyloma acuminatum.

Ingredients

Main ingredients and chemical names of this product: This product is a lignin anti-tumor ingredient extracted from plants of the genus Podophyllum in the family Botrytis. Its chemical name is [5R-(5alpha;,5alpha;beta;,8aalpha;,9alpha;)],5,8,8alpha;,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furan (3,4:6,7)naphtho-[2,3-d]-1,3-dioxetane-6(5alpha;H)-one. Molecular formula: C22H22O8, molecular weight: 414.41.

Appearance

This product is a colorless clear solution.

Indication

Genital warts on the external genitalia and perianal area of men and women.

Usage and Dosage

1. Before applying the medicine, clean the affected area with a disinfectant and astringent solution (such as potassium permanganate solution, etc.) and wipe it dry; 2. Use a special medicine swab to apply the liquid medicine to the wart, apply it all over the wart, no need to repeat and try to avoid the liquid medicine from contacting normal skin and mucous membranes; 3. The total amount of medicine should not exceed 1 ml. After applying the medicine, expose the affected area to let the liquid medicine dry; 4. Apply the medicine twice a day for 3 consecutive days, and stop the medicine for 4 days for observation as a course of treatment. If there are still residual lesions, you can repeat a course of treatment, but no more than three courses of treatment.

Adverse Reactions

1 Most patients may experience varying degrees of burning or tingling sensations, erythema, edema and erosion at the site of application after medication; 2 Erythema or superficial erosion may occur locally after shedding. These are common local reactions and do not require medication discontinuation. 3 Some patients may have severe local reactions and may be treated with anti-inflammatory and astringent cold compresses or creams, lotions and pastes, which can quickly and significantly alleviate symptoms. For those with severe local ulcers, edema and severe pain, treatment may be stopped if necessary. 4 A small number of patients did not experience any adverse reactions during treatment. 5 No systemic adverse reactions were observed with topical treatment.

Precautions

It is contraindicated for patients who are allergic to this drug or for those with unhealed wounds after surgery.

Special Population Medication

Precautions for children: There is currently a lack of experimental data on the use of drugs in children, and it is recommended that children should not use the drug. Precautions for pregnancy and lactation: It is forbidden for breastfeeding women. Precautions for the elderly:

Drug Interactions

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

Storage

Keep away from light and store in sealed container.

Packaging Specification

5 ml: 25 mg

Validity Period

24 months.

Manufacturer

Liaoning Huawei Pharmaceutical Co., Ltd.

  • Founded in:

    2000-04-08
  • Address:

    No. 62, Zhongxing Street, Yi County
  • Tax NO.:

    91210727121061977Q
  • Registered Funds:

    14.76 million yuan
  • Email:

Other Drugs of Liaoning Huawei Pharmaceutical Co., Ltd.

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