Pantoprazole Sodium Enteric-coated Capsules
Function and Efficacy
This product is a proton pump inhibitor for gastric parietal cells. It is relatively stable under neutral and weakly acidic conditions and rapidly activated under strongly acidic conditions. Its pH-dependent activation characteristics make it more selective for H and K-ATPase. This product can specifically inhibit the H and K-ATPase on the secretory microtubules and tubular vesicles in the cytoplasm of the parietal cell apical membrane, causing irreversible inhibition of the enzyme, thereby effectively inhibiting the secretion of gastric acid. Since H and K-ATPase are the last process of acid secretion in parietal cells, this product has a strong acid-suppressing ability. It can not only non-competitively inhibit gastric acid secretion caused by gastrin, histamine, and choline, but also inhibit some basal gastric acid secretion that is not affected by choline or H2 receptor blockers. When used with other drugs, this product has the advantage of small drug interactions. This product is metabolized through the I system of the cytochrome P450 enzyme system in hepatocytes, and can also be metabolized through the II system. When used with other drugs that are metabolized by the P450 enzyme system, the metabolic pathway of this product can be carried out through the II enzyme system, which makes it less likely to have competitive effects on the drug-metabolizing enzyme system and reduce the interaction between drugs in the body. It has no mutagenic, carcinogenic and teratogenic effects.
Ingredients
Pantoprazole sodium
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Pantoprazole SodiumIngredients |
This product is a proton pump inhibitor for gastric parietal cells. It is relatively stable under neutral and weakly acidic conditions and rapidly activated under strongly acidic conditions. Its pH-dependent activation characteristics make it more selective for H and K-ATPase. This product can specifically inhibit the H and K-ATPase on the secretory microtubules and tubular vesicles in the cytoplasm of the parietal cell apical membrane, causing irreversible inhibition of the enzyme, thereby effectively inhibiting the secretion of gastric acid. Since H and K-ATPase are the last process of acid secretion in parietal cells, this product has a strong acid-suppressing ability. It can not only non-competitively inhibit gastric acid secretion caused by gastrin, histamine, and choline, but also inhibit some basal gastric acid secretion that is not affected by choline or H2 receptor blockers. When used with other drugs, this product has the advantage of small drug interactions. This product is metabolized through the I system of the cytochrome P450 enzyme system in hepatocytes, and can also be metabolized through the II system. When used with other drugs that are metabolized by the P450 enzyme system, the metabolic pathway of this product can be carried out through the II enzyme system, which makes it less likely to have competitive effects on the drug-metabolizing enzyme system and reduce the interaction between drugs in the body. It has no mutagenic, carcinogenic and teratogenic effects. More |
138786-67-1 | 58 |
Appearance
This product is white or off-white loose block or powder, and the special solvent is colorless clear liquid.
Indication
It is mainly used for: ① peptic ulcer bleeding; ② acute gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs and the occurrence of ulcer bleeding under stress; ③ prevention of gastric acid reflux combined with aspiration pneumonia in patients after general anesthesia or major surgery and in patients with weakness and coma.
Usage and Dosage
Take one tablet orally every morning.
Adverse Reactions
Occasionally, dizziness, insomnia, drowsiness, nausea, diarrhea, constipation, rash and muscle pain may occur. Arrhythmia, increased aminotransferase, changes in renal function and decreased granulocytes may occur when used in large doses.
Precautions
It is contraindicated for those who are allergic to this product; it is contraindicated for pregnant and lactating women.
Special Population Medication
Precautions for children: The efficacy and safety data of this product for children have not been established. It is forbidden for infants and young children. Precautions for pregnancy and lactation: It is forbidden for pregnant and lactating women. Precautions for the elderly: No dosage adjustment is required.
Drug Interactions
Not yet clear.
Storage
Keep sealed.
Packaging Specification
40mg
Validity Period
24 months
Manufacturer
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
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Founded in:
1992-12-31 -
Address:
No. 866, Moganshan Road, Gongshu District, Hangzhou City, Zhejiang Province -
Tax NO.:
91330100609120774J -
Registered Funds:
872.30813 million yuan -
Website:
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Email: