Cyclosporine Soft Capsules

Cyclosporine is a new type of T lymphocyte regulator that can specifically inhibit the activity of helper T lymphocytes, but does not inhibit T lymphocytes, but promotes their proliferation. This product can also inhibit the activity of B lymphocytes: this product can also selectively inhibit interleukin-2 and interferon-β secreted by T lymphocytes, and can also inhibit interleukin-1 secreted by monocytes and phagocytes. While significantly inhibiting host cell immunity, it also has an inhibitory effect on humoral immunity. It can inhibit the production of anti-graft antibodies in the body, and thus has an anti-rejection effect. This product does not affect the function of phagocytes and does not produce obvious bone marrow suppression.

Main ingredients: [[(E)(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl Molecular formula: C62H111N11O12 Molecular weight: 1202.63

This product is a soft capsule, and the contents are light yellow or yellow oily liquid.

1. Prevent and treat rejection or graft-versus-host reaction of allogeneic organ transplantation or bone marrow transplantation. 2. Autoimmune diseases such as lupus nephritis and refractory nephrotic syndrome that are ineffective after other immunosuppressive agents.

Common oral dosage for adults: The initial dose is 12-15 mg/kg per day based on body weight, and the dose is gradually reduced after 1-2 weeks, generally reducing 5% of the initial dose each week, and the maintenance dose is about 5-10 mg/kg per day. For patients undergoing transplantation, the drug is administered 4-12 hours before transplantation.

1. Common gastrointestinal reactions include anorexia, nausea, vomiting, etc., gingival hyperplasia with bleeding and pain, and about 1/3 of users experience nephrotoxicity. Renal function impairment, hypertension, etc. may occur, such as increased serum creatinine and urea nitrogen, decreased glomerular filtration rate, etc. Gingival hyperplasia generally disappears 6 months after stopping the drug. Chronic, progressive nephrotoxicity usually occurs about 12 months after treatment. 2. Uncommon symptoms include convulsions, which may be caused by the nephrotoxicity and hypomagnesemia of this product. In addition, this product can also cause increased aminotransferase, cholestasis, hyperbilirubinemia, hyperglycemia, hirsutism, hand tremor, hyperuricemia with thrombocytopenia, microangiopathic hemolytic anemia, paresthesia of the limbs, painful cramps of the lower limbs, etc. In addition, there are reports that this product can promote ADP-induced platelet aggregation and increase blood

1. This product is contraindicated when there is a viral infection: such as chickenpox, herpes zoster, etc. 2. This product is contraindicated for those who are allergic to it.

Precautions for children: Common dosage for children: Initial dose for organ transplantation is 6-11 mg/kg per day based on body weight, and maintenance dose is 2-6 mg/kg per day. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients are prone to renal insufficiency, so Xinsaisiping should be used with caution.

1. This product can increase the plasma concentration of this product when used in combination with estrogen, androgen, cimetidine, diltiazem, erythromycin, ketoconazole, etc. Therefore, the liver and kidney toxicity of this product may be increased. Therefore, caution should be exercised when used in combination with the above drugs, and the patient's liver and kidney function and the blood concentration of this product should be monitored. 2. When used in combination with non-steroidal anti-inflammatory analgesics such as indomethacin, the risk of renal failure may increase. 3. When using this product, if the stored blood stored for more than 10 days is transfused or this product is used in combination with potassium-sparing diuretics, high potassium-containing drugs, etc., blood potassium may increase. 4. Used in combination with liver enzyme inducers: Because it can induce liver microsomal enzymes, it increases the metabolism of this product. Therefore, the dosage of this product must be adjusted. 5. Used in combination with immunosuppressants such as adrenocortical hormones, azathioprine, chlorambucil, cyclophosphamide, etc. It may increase the risk of infection and lymphoproliferative diseases, so caution should be used. 6. When used in combination with lovastatin (a lipid-lowering drug) in patients with heart transplantation, the risk of rhabdomyolysis and acute renal failure may be increased. 7. When used in combination with drugs that can cause nephrotoxicity, the toxicity to the kidneys may be increased. If renal insufficiency occurs, the dosage of the drug should be reduced or the drug should be discontinued.

Protect from light, seal tightly and store in a cool place.

25 mg

18 months

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

• Founded in:

  1992-12-31

• Address:

  No. 866, Moganshan Road, Gongshu District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100609120774J

• Registered Funds:

  872.30813 million yuan

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