Potassium Sodium Hydrogen Citrate Granules

Urolithiasis is a general term for diseases caused by urinary stones, which are formed by crystals in the urine. The pathogenesis of urinary stones is related to the presence of factors that promote the formation of stones, such as excessive salt excretion, urine acidity, and decreased urine volume, preformed cores (such as uric acid crystals and other stones), and abnormal inhibitors of crystal formation. Idiopathic hypercalciuria [urinary calcium >300mg/d (>7.5mmol/d) in men and >250mg/d (6.2mmol/d) in women] is a hereditary disease that occurs in 50% of men with calcium stones and 75% of women with calcium stones because citrate can normally bind to urinary calcium to form soluble calcium citrate salts. Potassium sodium hydrogen citrate acts mainly through the bases in the HCO3-1 salts in the body's metabolites. Improvement of acidic urine: The test of acidic urine induced by ammonium chloride in rats showed that potassium sodium hydrogen citrate granules have a dose-dependent effect in preventing acidic urine. For rats with hyperuricemia induced by uric acid, this product can reduce acidic urine and the concentration of HCO3-1 in urine, thereby increasing the pH value in urine. Improvement of acidosis: For rats with acidosis induced by glanders, this product has a dose-dependent effect of increasing blood pH. By increasing the pH value of urine and the excretion of citrate, the calcium ion concentration in urine is reduced. This change makes it easy for salts in urine that form stones to crystallize. The resulting reduction in calcium ion concentration can reduce the saturation of calcium salts in urine that can form stones. The increase in pH value can increase the solubility of uric acid and cystine stones. Through in vitro and animal experiments, the role of potassium citrate in the formation of calcium oxalate was studied. The results showed that after adding potassium citrate to the test tube and then giving oxalic acid load, the formation of calcium oxalate crystals was significantly reduced, indicating that potassium citrate has a significant inhibitory effect on the formation of calcium oxalate crystals. All rats that were only given lithogenic drugs had moderate or large amounts of calcium oxalate crystal particles formed in the renal parenchyma, while the crystal particles in the renal parenchyma of the group that was given potassium citrate at the same time were significantly reduced. The calcium and oxalic acid content in the wet kidneys of the two groups of experimental rats was calculated and it was found that the calcium and oxalic acid content in the kidneys of the potassium citrate group was significantly lower than that of the control group, p < 0.05, indicating that potassium citrate has a good stone prevention effect.

The main ingredients and chemical name of this product are: Sodium potassium hydrogen citrate (6:6:3:5)

For dissolving uric acid stones and preventing the formation of new stones, as a maintenance treatment for cystine stones and cystinuria.

Occasionally mild gastrointestinal discomfort may occur.

Potassium sodium bicitrate should not be used in patients with acute or chronic renal failure or when sodium chloride is absolutely contraindicated. Potassium sodium bicitrate is also contraindicated in patients with severe acid-base imbalance (base metabolism) or chronic urinary tract urea-degrading bacterial infections.

Any increase in extracellular potassium concentration will reduce cardiac glucose metabolism, while any decrease in extracellular potassium concentration will increase the incidence of arrhythmias. Aldosterone antagonists, potassium-sparing diuretics, ACE inhibitors, nonsteroidal anti-inflammatory drugs and peripheral analgesics can reduce renal potassium excretion. Remember that 1 gram of potassium sodium citrate contains 0.172 grams or 4.4 mmol potassium. If a low-sodium diet is required, remember that 1 gram of potassium sodium citrate contains 0.1 grams or 4.4 mmol sodium (equivalent to 0.26g sodium chloride). Drugs containing citrate increase aluminum absorption when given simultaneously with aluminum-containing drugs. If these two drugs must be used, the interval between the administration of the two drugs should be at least 2 hours. The main manifestations of kidney stones: 1. Clinical manifestations vary greatly from person to person, depending on the cause, composition, size, number, location, mobility, presence or absence of obstructive infection and the degree of pathological damage to the renal parenchyma. Mild cases may be completely asymptomatic, while severe cases may cause anuria, renal failure, toxic shock and death. 2. When the stone is stuck at the junction of the renal pelvis and ureter or descends in the ureter, renal colic may occur, which is a sudden onset of paroxysmal knife-like pain. The pain is severe and unbearable. The patient is restless. The pain radiates from the waist or flank to the bladder area, the vulva and the inner thigh. Sometimes there is sweating, nausea and vomiting. 3. Because the stone causes serious damage to the mucosa, there is often gross hematuria. Pain and hematuria are often induced when the patient is more active. When the stone is complicated by infection, pus cells appear in the urine, and there are symptoms of frequent urination and painful urination. 4. When acute pyelonephritis or pyonephrosis occurs, there may be systemic symptoms such as fever, chills, and chills. Bilateral upper urinary tract stones or complete obstruction of kidney stones can lead to anuria. Self-care points for kidney stones: 1. Those who experience nausea and vomiting should seek medical attention in time, replenish fluids according to the doctor's orders, and pay attention to electrolyte balance. 2. Drink plenty of water, at least 2000~3000ml of water per day. In addition to drinking a lot of water during the day, you also need to drink 500ml of water before going to bed, and drink another 200ml of water after getting up to urinate during sleep. 3. Increase physical activities, such as jumping, to make stones easier to expel. 4. Proper diet adjustment can prevent the regeneration of stones. Patients with calcium stones should eat less calcium-rich foods such as milk, and patients with oxalate stones should eat less spinach, potatoes, beans and strong tea. Phosphate stone patients should use a low-phosphorus, low-calcium diet and take ammonium chloride orally to acidify the urine. Patients with urate stones should eat less purine-containing foods, such as animal offal, meat and beans, and take sodium bicarbonate orally to alkalinize the urine, which is also conducive to the dissolution of urate stones.

There are no special restrictions on the storage of the drug after opening the drug package. If the drug has been dissolved in water and prepared into a solution, it should be taken immediately.

100g

Wuhan Weiao Pharmacauti Cal Co., Ltd.

• Founded in:

  1996-10-30

• Address:

  Wuhan University Science and Technology Park, Jiangxia Avenue, East Lake New Technology Development Zone, Wuhan

• Tax NO.:

  91420100616432784K

• Registered Funds:

  30 million yuan

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