Diclofenac Sodium Tablets

Diclofenac is a non-steroidal anti-inflammatory analgesic derived from phenylacetic acid. Its mechanism of action is to inhibit the activity of cyclooxygenase, thereby blocking the conversion of arachidonic acid into prostaglandins. At the same time, it can also promote the combination of arachidonic acid with triglycerides (triacylglycerols), reduce the concentration of free arachidonic acid in cells, and indirectly inhibit the synthesis of leukotrienes. Diclofenac is one of the stronger non-steroidal anti-inflammatory drugs. Its inhibitory effect on prostaglandin synthesis is stronger than that of aspirin and indomethacin. Non-clinical toxicology study: Oral administration of diclofenac sodium to rats at 2 mg/kg per day, long-term observation, no increase in tumor incidence was found. In a two-year study on mice, 2 mg/kg was used daily, and no tumor-prone tendency was found. Various mutation studies did not find that diclofenac sodium induced gene mutations. Rats were given 4 mg/kg per day, and no infertility occurred in both males and females. Acute toxicity test results: oral LD50 for rats is 150 mg/kg; oral LD50 for mice is 390 mg/kg.

The main ingredient is diclofenac.

This product is white tablets.

1. Acute and chronic rheumatoid arthritis, acute and chronic ankylosing spondylitis, and osteoarthritis. 2. Periarthritis of shoulder, bursitis, tendinitis, and tenosynovitis. 3. Low back pain, sprains, strains, and other soft tissue injuries. 4. Acute gout. 5. Dysmenorrhea or adnexitis, toothache, and postoperative pain. 6. Pain and inflammation after trauma, such as sprains, muscle strains, etc. 7. Severe infectious pain and inflammation of the ear, nose, and throat (such as tonsillitis, otitis, sinusitis, etc.), which should be treated with anti-infective drugs at the same time.

Oral administration: once a day, or 1 to 2 times a day, or as directed by a doctor, after meals.

1. May cause gastrointestinal reactions such as headache and abdominal pain, constipation, diarrhea, burning sensation in the stomach, nausea, indigestion, etc. 2. Occasionally headache, dizziness, and vertigo. Elevated serum glutamate oxaloacetate aminotransferase (GOT) and serum glutamate pyruvate aminotransferase (GPT). 3. Rarely, decreased renal function may lead to water and sodium retention, manifested by low urine volume, facial edema, and sudden weight gain. Rarely, it may cause arrhythmia, tinnitus, etc. 4. It may cause bone marrow suppression or aggravate it.

1. Patients with allergic reactions, asthma, urticaria or other allergic reactions to this product, aspirin or other non-steroidal anti-inflammatory drugs. 2. Patients with peptic ulcers.

Precautions for children: Not suitable for children under 16 years old. Precautions for pregnancy and lactation: Generally not suitable for use during pregnancy, especially in the last 3 months of pregnancy. Not suitable for lactating women. Precautions for the elderly: Use with caution.

Diclofenac can increase the plasma concentration of digoxin and lithium-containing preparations and reduce the renal excretion of methotrexate. Therefore, special caution should be exercised when used in combination with these drugs.

Keep away from light, tightly closed and in a dry place.

25mg

24 months

Shanxi Taiyuan Jinyang Pharmaceutical Factory

• Founded in:

  1989-08-29

• Address:

  No. 22, Minhang South Road, Xiaodian District, Taiyuan City

• Tax NO.:

  911401051100866506

• Registered Funds:

  11.56938626 million yuan

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