Diphylline Sodium Chloride Injection
Function and Efficacy
The antiasthmatic effect of dihydroxypropylphylline is similar to that of theophylline. Its cardiac excitatory effect is only 1/20-1/10 of that of aminophylline, and its effect on the heart and nervous system is less, so it is especially suitable for asthma patients with tachycardia. This product has a direct relaxant effect on respiratory smooth muscle. Its mechanism of action is relatively complex. In the past, it was believed that it was caused by inhibiting phosphodiesterase and increasing the intracellular cAMP content. In recent years, studies have shown that the bronchodilator effect of theophylline is partly due to the release of endogenous adrenaline and norepinephrine; in addition, theophylline is a purine receptor blocker that can counteract the contractile effect of adenine and other substances on the respiratory tract. Theophylline can enhance the contractility of the diaphragm, especially when the diaphragm contraction is weak, so it helps to improve respiratory function.
Ingredients
The main ingredients of this product are: Dihydroxypropyltheophylline Chemical name: 1,3-dimethyl-7-(2,3-dihydroxypropyl)-3,7-dihydro-1H-purine-2,6-dione. Chemical structure: Molecular formula: C10H14N4O4 Molecular weight: 254.25 This product is added with sodium chloride to adjust isotonicity Chemical name: Sodium chloride Molecular formula: NaCl Molecular weight: 58.44
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| DiprophyllineIngredients |
Its antiasthmatic effect is similar to that of theophylline, and its cardiac excitatory effect is only 1/20-1/10 of that of aminophylline. It has less effect on the heart and nervous system, and is especially suitable for asthma patients with tachycardia. It has a direct relaxant effect on respiratory smooth muscle, partly by inhibiting phosphodiesterase to increase intracellular cAMP, and partly as a result of the release of endogenous adrenaline and noradrenaline. At the same time, as a purine receptor blocker, it can counteract the contractile effect of adenine on the respiratory tract, and can enhance the contractility of the diaphragm to improve respiratory function. More |
479-18-5 | 11 | |
| Sodium chlorideExcipients |
Used to adjust isotonicity, no specific pharmacological effects are mentioned. More |
7647-14-5 | 43 |
Appearance
This product is a colorless clear liquid.
Indication
It is suitable for bronchial asthma, asthmatic bronchitis, obstructive pulmonary emphysema, etc. to relieve wheezing symptoms. It is also used for asthma caused by cardiogenic pulmonary edema.
Usage and Dosage
The dosage of this product needs to be adjusted according to the patient's symptoms and reactions. Common dosage for adults: 0.25-0.75g (1-3 bottles) at a time.
Adverse Reactions
Similar to theophylline, excessive doses may cause nausea, vomiting, irritability, insomnia, tachycardia, arrhythmia, and even fever, dehydration, convulsions, and even respiratory and cardiac arrest.
Precautions
It is contraindicated in patients who are allergic to this product, those with active peptic ulcers and uncontrolled convulsive diseases.
Special Population Medication
Precautions for children: The plasma clearance rate of newborns may be reduced and the serum concentration may increase, so it should be used with caution. Precautions for pregnancy and lactation: This product can pass through the placental barrier and can also be secreted into breast milk and excreted with breast milk. It should be used with caution by pregnant women, parturients and lactating women. Precautions for the elderly: The plasma clearance rate of the elderly is reduced and the potential toxicity is increased. It should be used with caution in patients over 55 years old.
Drug Interactions
1. When used in combination with lithium salts, it can increase the renal excretion of lithium, affecting the effect of lithium salts. 2. When used in combination with caffeine or other xanthine drugs, it can increase their effects and toxicity. 3. When used in combination with propranolol, the bronchodilator effect of this product may be inhibited.
Storage
Keep away from light and store in airtight container.
Packaging Specification
100ml: 0.25g of diphylline and 0.9g of sodium chloride
Validity Period
18 months
Manufacturer
Chimin HEALTH Management Co., Ltd.
-
Founded in:
1996-12-24 -
Address:
No. 888, Beiyuan Road, Huangyan District, Taizhou City, Zhejiang Province -
Tax NO.:
91330000610008739T -
Registered Funds:
525.090615 yuan -
Website:
-
Email: