Trimetazidine Hydrochloride Capsules
Function and Efficacy
Anti-anginal drugs. It has the effect of antagonizing adrenaline, norepinephrine and vasopressin, can reduce vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, thereby improving the balance of myocardial oxygen supply and demand. It can also increase tolerance to cardiac glycosides. Controlled trials in patients with angina pectoris showed: 1. This drug can increase the exercise test tolerance of patients with angina pectoris, delay exercise-induced myocardial ischemia from d15 of treatment, reduce ischemia, but does not cause hemodynamic changes. 2. Limiting rapid blood pressure fluctuations does not cause significant changes in heart rate, and significantly reduces the frequency of angina attacks. 3. The dosage of nitroglycerin is significantly reduced. Mechanism of action of trimetazidine: The effect on ischemic myocardium may be direct cell protection. By preserving the energy metabolism in ischemic cells and preventing the decrease of intracellular ATP levels, it ensures the perfect function of ion pumps and normal transport of transmembrane sodium-potassium pumps while maintaining the stability of the intracellular environment, reduces intracellular acidosis, prevents the accumulation of sodium and calcium in myocardial cells, protects cell contractile function and limits cell lysis and endothelial damage caused by oxygen free radicals.
Ingredients
The main ingredient of this product is trimetazidine hydrochloride.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| Trimetazidine dihydrochlorideIngredients |
Anti-angina drug. It has the effect of antagonizing adrenaline, norepinephrine and vasopressin, can reduce vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, thereby improving the balance of myocardial oxygen supply and demand. It can also increase tolerance to cardiac glycosides. By preserving the energy metabolism in ischemic cells and preventing the decrease of intracellular ATP levels, it ensures the perfect function of ion pumps and normal transmembrane sodium-potassium pump transport while maintaining the stability of the intracellular environment, reduces intracellular acidosis and prevents the accumulation of sodium and calcium in myocardial cells, protects cell contraction function and limits cell lysis and endothelial damage caused by oxygen free radicals. More |
13171-25-0 | 32 |
Appearance
This product is in the form of capsules.
Indication
Usage and Dosage
Take 20 mg at a time, 3 times a day, with warm water before meals.
Adverse Reactions
Very few patients experience gastrointestinal discomfort (nausea, vomiting).
Precautions
Not yet clear.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Animal experiments did not indicate teratogenic effects; however, due to the lack of clinical data, the risk of teratogenicity cannot be ruled out. Therefore, from a safety perspective, it is best to avoid taking the drug during pregnancy. Due to the lack of data on secretion through breast milk, it is recommended not to breastfeed during treatment. Precautions for the elderly: Not yet clear.
Drug Interactions
If you need to take it with other medicines, please consult your doctor or pharmacist for details.
Storage
Sealed, store in a dry place.
Packaging Specification
20mg
Validity Period
24 months
Manufacturer
Beijing Jialin Pharmaceutical Co., Ltd.
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Founded in:
1977-08-05 -
Address:
No. 2 Jiuxianqiao Road, Dashanzi, Dongzhimenwai, Chaoyang District, Beijing -
Tax NO.:
911101051016610948 -
Registered Funds:
30.5 million yuan -
Website:
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Email: