Roxithromycin Tablets
Function and Efficacy
This product is a semi-synthetic 14-membered macrolide antibiotic. Its antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. Its effect on Gram-positive bacteria is slightly worse than that of erythromycin. Its effect on Legionella pneumophila is stronger than that of erythromycin. Its antimicrobial effect on Chlamydia pneumoniae and Mycoplasma pneumoniae is similar to or slightly stronger than that of erythromycin. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor (P site), blocking the binding of transfer RNA (t-RNA) to the P site. It also blocks the transfer of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis.
Ingredients
The main ingredient of this product is roxithromycin. Chemical name: 9-{O-[(2-methoxyethoxy)-methyl]oxime}erythromycin.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| RoxithromycinIngredients |
This product is a semi-synthetic 14-membered macrolide antibiotic, and its antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. It is slightly less effective than erythromycin against Gram-positive bacteria, and stronger than erythromycin against Legionella pneumophila. Its antimicrobial effect against Chlamydia pneumoniae, Mycoplasma pneumoniae, and Ureaplasma urealyticum is similar to or slightly stronger than that of erythromycin. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor (P position), blocking the transfer RNA (t-RNA) from binding to the P position, and also blocking the transfer of the polypeptide chain from the acceptor position (A position) to the P position, thereby inhibiting bacterial protein synthesis. More |
80214-83-1 | 28 |
Appearance
This product is a film-coated tablet, which appears white or off-white after removing the coating.
Indication
This product is suitable for pharyngitis and tonsillitis caused by Streptococcus pyogenes, sinusitis, otitis media caused by sensitive bacteria, acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia caused by Mycoplasma pneumoniae or Chlamydia pneumoniae; urethritis and cervicitis caused by Chlamydia trachomatis; skin and soft tissue infections caused by sensitive bacteria
Usage and Dosage
Take orally on an empty stomach. The general course of treatment is 5 to 12 days. Adults can take 150 mg twice a day or 300 mg once a day. Children can take 2.5 to 5 mg/kg twice a day.
Adverse Reactions
The main adverse reactions are gastrointestinal reactions such as abdominal pain, diarrhea, nausea and vomiting, but the incidence is significantly lower than that of erythromycin. Occasionally, there are rash, itching, dizziness, headache, abnormal liver function (elevated ALT and AST), decreased peripheral blood cells, etc.
Precautions
This product is contraindicated in patients who are allergic to erythromycin or other macrolide drugs
Special Population Medication
Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. A dosage of less than 0.05% is excreted into breast milk. Although there are reports that it has little effect on infants, it is still necessary to consider whether to stop breastfeeding. Precautions for the elderly: If there is no significant change in pharmacokinetics in the elderly, there is no need to adjust the dose.
Drug Interactions
1. It cannot be used with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride. 2. It has little effect on the metabolism of aminophylline and has little effect on carbamazepine, warfarin, ranitidine and other antacids.
Storage
Sealed, store in a dry place.
Packaging Specification
0.15 g
Validity Period
24 months
Manufacturer
Zhejiang Zhenyuan Pharmaceutical Co., Ltd.
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Founded in:
1997-11-19 -
Address:
No. 61, Yuedong North Road, Yuecheng District, Shaoxing City, Zhejiang Province -
Tax NO.:
913306022547351704 -
Registered Funds:
300 million yuan -
Website:
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Email: