Trimebutine Maleate Dry Suspension

The results of in vitro tests indicate that this product can reduce the amplitude of the autonomic movement of the circular muscles in the vestibule of guinea pigs at a concentration of 10-5g/ml, increase the frequency and amplitude of irregular weak movements, and make them tend to regular rhythmic contractions. Intravenous injection of 3mg/kg of this product in anesthetized dogs with thoracic vagus nerve cut can make the irregular movement of the stomach tend to regularize. After intravenous injection of 1mg/kg of this product in humans, it was found that it can inhibit the movement of hypermotility muscles in the pylorus of patients with digestive system diseases, and can also enhance the movement of hypomotility muscles.

Chemical name: (±)-2-dimethylamino-2-phenylbutyl-3,4,5-trimethoxybenzoate maleate

This product is white or off-white powder or granules with aromatic odor and sweet taste.

1. Improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, abdominal borborygmus, abdominal pain, diarrhea, constipation, etc. caused by gastrointestinal dysfunction. 2. Irritable bowel syndrome.

Oral administration, take with cold boiled water. Adults take one to two bags each time, three times a day. Note: This product must be taken within 30 minutes after brewing. The recommended amount of water to add is 20ml per bag, which can be adjusted appropriately according to specific circumstances.

Occasionally, there may be thirst, numbness in the mouth, abdominal borborygmi, diarrhea, constipation, tachycardia, drowsiness, dizziness, headache, rash, increased ALT and AST, etc., with an incidence rate of about 0.4%.

It is contraindicated for those who are allergic to this product.

Precautions for children: Children should use with caution. Precautions for pregnancy and lactation: Pregnant women should take this medicine under the guidance of a doctor. If you find out you are pregnant while taking the medicine, you need to inform your doctor and ask if you can continue to take the medicine. Precautions for the elderly: Elderly patients usually have weaker physiological functions. When taking this medicine, you should consult a doctor and reduce the dosage as appropriate.

1 Tubocurarine: Trimebutine maleate can enhance the effect of tubocurarine. 2 Procainamide: Trimebutine maleate and procainamide can produce a synergistic antivagal effect on sinoatrial node conduction. Heart rate and electrocardiogram should be monitored. 3 Cisapride: Trimebutine maleate can antagonize cisapride pharmacologically, weakening the gastrointestinal motility of cisapride.

Store in a sealed, dry place. The validity period is tentatively 24 months.

4g:0.1g

24 months

Hainan Poly Pharm. Co., Ltd.

• Founded in:

  1992-07-14

• Address:

  Guilinyang Economic Development Zone, Meilan District, Haikou City

• Tax NO.:

  91460000620000247L

• Registered Funds:

  448.350021 million yuan

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