Metformin Hydrochloride Tablets

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: ① Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization; ② Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc.; ③ Inhibit hepatic gluconeogenesis and reduce hepatic glucose output; ④ Inhibit intestinal wall cells from taking up glucose; ⑤ Inhibit cholesterol biosynthesis and storage, and reduce blood triglyceride and total cholesterol levels. Unlike the effect of insulin, this product has no effect on promoting fat synthesis and no obvious hypoglycemic effect on normal people. It generally does not cause hypoglycemia when used alone for type 2 diabetes.

The main ingredient of this product is metformin hydrochloride. Its chemical name is 1,1-dimethylbiguanide hydrochloride. Molecular formula: C4H11N5HCl Molecular weight: 165.63

This product is white tablets.

It is used for patients with type 2 diabetes who are not satisfied with diet control alone, especially those who are obese and have hyperinsulinemia. This drug not only has the effect of lowering blood sugar, but also may reduce weight and hyperinsulinemia. It can be effective for patients with poor efficacy of certain sulfonylureas. For example, it is more effective when used in combination with sulfonylureas, intestinal glycosidase inhibitors or thiazolidinediones hypoglycemic drugs than when used alone. It can also be used for patients treated with insulin to reduce the amount of insulin.

1. Take the medicine as directed by the doctor. This product should be started at a small dose and the dose should be gradually increased according to the patient's condition. 2. Usually the starting dose of this product is 0.5 grams twice a day; or 0.85 grams once a day; taken with meals. 3. It can be increased by 0.5 grams per week, or 0.85 grams every 2 weeks, gradually increasing to 2 grams per day, taken in divided doses. 4. The maximum recommended dose for adults is 2550 mg per day. For patients who need to further control blood sugar, the dose can be increased to 2550 mg per day (that is, 0.85 grams each time, three times a day). 5. When the daily dose exceeds 2 grams, in order to better tolerate, the drug is best taken in divided doses with three meals.

1 Common symptoms include: nausea, vomiting, diarrhea, metallic taste in the mouth. 2 Sometimes there is weakness, tiredness, dizziness, and rash. 3 Although the incidence of lactic acidosis is very low, it should be noted. Clinical manifestations include vomiting, abdominal pain, hyperventilation, mental disorder, and increased lactic acid concentration in the blood that cannot be explained by uremia, ketoacidosis, or salicylic acid poisoning. 4 It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce megaloblastic anemia, and also cause malabsorption.

The following situations should not be used. 1. Type II diabetes with ketoacidosis, liver and kidney dysfunction (serum creatinine exceeds 1.5mg/dl), pulmonary insufficiency, heart failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinical hypotension and hypoxia. 2. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic fundus lesions). 3. Before intravenous pyelography or arterial angiography. 4. Alcoholics. 5. Patients with severe heart and lung diseases. 6. Patients with vitamin B12, folic acid and iron deficiency. 7. Patients with poor systemic condition (such as malnutrition, dehydration).

Precautions for children: The maximum daily dose of this product for patients with type 2 diabetes aged 10-16 years is 2000 mg. This product is not recommended for children under 10 years old. Precautions for pregnancy and lactation: This product is not recommended for pregnant women. Lactating women should use this product with caution. If this product must be used, breastfeeding should be stopped. Precautions for the elderly: Elderly patients over 65 years old should use this product with caution and have their renal function checked regularly. The maximum dose is usually not used. This product is not recommended for patients over 80 years old unless their creatinine clearance test shows that their renal function is not reduced.

1. When used in combination with insulin, the hypoglycemic effect is enhanced and the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin) and may cause bleeding tendency. 3. If this product is taken with alcoholic beverages, abdominal pain, acidemia and hypothermia may occur. 4. When this product is used in combination with sulfonylureas, it may cause hypoglycemia.

Keep sealed.

0.5g

24 months.

Kunshan Peili Pharmaceutical Co., Ltd.

• Founded in:

  1995-03-02

• Address:

  No. 27, Lufeng West Road, Lujia Town, Kunshan City, Jiangsu Province

• Tax NO.:

  91320583608279361D

• Registered Funds:

  $3.3 million

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