Berberine Trimethoprim Capsules

Berberine hydrochloride and trimethoprim have synergistic antibacterial effects. Berberine hydrochloride has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria in vitro, among which hemolytic streptococci, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Salmonella typhi, Corynebacterium diphtheriae, etc. have stronger inhibitory effects. It also has a certain inhibitory effect on amoeba. Trimethoprim mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis. Therefore, the antibacterial effect of the two combined is stronger than that of a single drug, and the drug-resistant strains are reduced.

This product is a compound preparation, and its components are: each tablet contains 100 mg of berberine hydrochloride and 50 mg of trimethoprim.

This product is a capsule, the contents are yellow granules, odorless and bitter.

Gastroenteritis, bacillary dysentery and other intestinal infections caused by sensitive bacteria.

Take 1-3 capsules at a time, 3 times a day.

Nausea, vomiting, drug rash, and diarrhea will disappear after stopping the drug; itching and rash may occur, and occasionally severe exudative erythema multiforme may occur; aseptic meningitis may occasionally occur, with headaches, stiff neck, etc.

1. Patients who are allergic to berberine hydrochloride, trimethoprim and sulfonamides are prohibited from using this product. 2. Children with glucose-6-phosphate dehydrogenase deficiency are prohibited from using this product. 3. Newborns and infants under 2 months old are prohibited from using this product.

Precautions for children: 1. Berberine hydrochloride can cause hemolytic anemia and lead to jaundice, so it is contraindicated for children with glucose-6-phosphate dehydrogenase deficiency. 2. The trimethoprim in this product may interfere with the folic acid metabolism of breastfeeding infants. Newborns and infants under 2 months old should not use this drug; children are in the growth and development period, and their liver and kidney functions are not yet perfect, so the dosage should be reduced as appropriate. Precautions for pregnancy and lactation: Since trimethoprim can cross the placental barrier, the blood drug concentration in the fetal circulation and amniotic fluid is close to the maternal blood drug concentration. Therefore, this product must be weighed after weighing the pros and cons to decide whether to use it during pregnancy. Precautions for the elderly: Elderly patients have reduced resistance and weakened metabolic capacity. When taking this product, they should pay attention to blood tests. If serious adverse reactions occur, the medication should be stopped immediately.

1. The interaction between berberine hydrochloride and other drugs is still unclear; 2. Trimethoprim: (1) When used simultaneously with bone marrow suppressants, the chances of leukopenia and thrombocytopenia increase; (2) When used simultaneously with dapsone, the blood concentrations of both drugs increase.

Keep away from light and store in airtight container.

Compound

36 months

MAN Yuen (FUZHOU) MEDICINE Co., Ltd.

• Founded in:

  1993-03-08

• Address:

  Fuxing Investment Zone, Gushan Township, Jin'an District, Fuzhou City

• Tax NO.:

  913501006113151673

• Registered Funds:

  $1.5 million

• Email:

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