Nylestradiol tablets
Function and Efficacy
Estrogen drugs. This product is a derivative of estriol. Estriol is a metabolite of estradiol. Its pharmacological effects are similar to those of estradiol, but its biological activity is low, so its effect on endometrial proliferation is also weak. It is suitable for estrogen replacement therapy for perimenopausal women. The introduction of cyclopentyl ether at the 3rd position increases its lipophilicity, which is beneficial for intestinal absorption and storage in adipose tissue, and then slowly released to play a long-term effect. The introduction of acetylene at the 17th position enhances the estrogen activity.
Ingredients
The main component of this product is nialstradiol. Its chemical name is: 3-(cyclopentyloxy)-19-nor-17-pregnane-1,3,5(10)-triene-20-yne-16α,17α-diol.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| NilestriolIngredients |
Estrogen drugs. This product is a derivative of estriol. Its pharmacological effects are similar to those of estradiol, but its biological activity is low, so its effect on endometrial proliferation is also weak. It is suitable for estrogen replacement therapy for perimenopausal women. The introduction of cyclopentyl ether at the 3rd position increases its lipophilicity, which is beneficial for intestinal absorption and storage in adipose tissue, and then slowly released to play a long-term effect. The introduction of acetylene at the 17th position enhances the estrogen activity. More |
39791-20-3 | 2 |
Appearance
This product is white tablets
Indication
It is clinically used for menopausal or climacteric syndrome caused by estrogen deficiency, such as hot flashes, sweating, headache, dizziness, fatigue, irritability, nervousness, vulvar dryness, senile vaginitis, etc.
Usage and Dosage
Oral: 5 mg once a month; or 2 mg once every two weeks. After symptoms improve, the maintenance dose is 1-2 mg each time, twice a month, and a course of treatment is 3 months.
Adverse Reactions
(1) Mild gastrointestinal reactions, manifested as nausea, vomiting, abdominal distension, headache, and dizziness; (2) Breakthrough bleeding; (3) Breast tenderness and increased vaginal discharge; (4) Hypertension; (5) Occasionally, liver function damage.
Precautions
It is contraindicated for patients with a history of estrogen-dependent diseases (such as breast cancer, uterine, endometrial cancer, cervical cancer, large uterine fibroids, etc.), thrombosis, and hypertension.
Special Population Medication
Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Not for use by pregnant women. Precautions for the elderly: Not yet clear.
Drug Interactions
Not yet clear.
Storage
Sealed, store in a dry place.
Packaging Specification
2mg
Validity Period
36 months.
Manufacturer
Hunan Zhengqing Pharmaceutical Co., Ltd.
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Founded in:
1994-06-22 -
Address:
No. 7, Fortune Road, Huaihua High-tech Industrial Development Zone, Hunan -
Tax NO.:
91431200183808108W -
Registered Funds:
204.270346 million yuan -
Website:
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Email: