 Home > Encyclopedia > Nilestriol

Nilestriol

Nilestriol structure

CAS No:
39791-20-3
Formula:
C25H32O3
Chemical Name:
Nilestriol
Synonyms:
19-Norpregna-1,3,5(10)-trien-20-yne-16,17-diol,3-(cyclopentyloxy)-,(16α,17α)-;(16α,17α)-3-(Cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yne-16,17-diol;17α-Ethynylestriol 3-cyclopentyl ether;3-Cyclopentyloxy-19-nor-17α-pregna-1,3,5(10)-trien-20-yne-16α,17β-diol;Nylestriol;EE3CPE;Nilestriol;WeiNiAn
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Request for Quotation

Nilestriol Basic Attributes

Molecular Weight：

380.52

Exact Mass：

380.52

UNII：

7JA3B3IALU

Characteristics

PSA：

49.69000

XLogP3：

5.74

Density：

1.2±0.1 g/cm3

Melting Point：

162-165 °C @ Solvent: Diethyl ether, Hexane

Boiling Point：

521.7±50.0 °C at 760 mmHg

Flash Point：

269.3±30.1 °C

Refractive Index：

1.612

Drug Information

MeSH：

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. (See all compounds classified as Estrogens.)

MeSH Entry Terms：

17 alpha-ethinylestriol 3-cyclopentyl ether

Nilestriol Use and Manufacturing

Estrogen.

Computed Properties

Molecular Weight:380.5
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:380.23514488
Monoisotopic Mass:380.23514488
Topological Polar Surface Area:49.7
Heavy Atom Count:28
Complexity:645
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Estrogen drugs. This product is a derivative of estriol. Its pharmacological effects are similar to those of estradiol, but its biological activity is low, so its effect on endometrial proliferation is also weak. It is suitable for estrogen replacement therapy for perimenopausal women. The introduction of cyclopentyl ether at the 3rd position increases its lipophilicity, which is beneficial for intestinal absorption and storage in adipose tissue, and then slowly released to play a long-term effect. The introduction of acetylene at the 17th position enhances the estrogen activity.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Nylestradiol tablets
Ingredients	The main component of this product is nialstradiol. Its chemical name is: 3-(cyclopentyloxy)-19-nor-17-pregnane-1,3,5(10)-triene-20-yne-16α,17α-diol.
Indication	Not yet clear.
Specifications	2mg
Manufacturer	Hunan Zhengqing Pharmaceutical Co., Ltd.

Nylestradiol tablets
Ingredients	The main ingredient of this product is nialstradiol
Indication	Not yet clear
Specifications	5 mg

Nylestradiol
Manufacturer	Langfang Gaobo Jingband Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Shanghai New Hualian Pharmaceutical Co., Ltd.

China
Active
Langfang Gaobo Jingband Pharmaceutical Co., Ltd.

China
Active