3-Amino-2,6-piperidinedione hydrochloride

2,6-Dioxopiperidine-3-ammoniumchloride;2,6-Dioxopiperidine-3-ammonium;LenalidomideImpurity6HCl;Pomalidomide/lenalidomideINTII;3-Amino-piperidine-2,6-dioChemicalbookne[2353-44-8]at262USD,pleasebenoted,whatweprovideisHClsaltform;2,6-dioxopiperidin-3-aminiumchloride;PomalidomideImpurity6;6-piperidinedionehydrochloride

InChI=1S/C5H8N2O2.ClH/c6-3-1-2-4(8)7-5(3)9;/h3H,1-2,6H2,(H,7,8,9);1H

3-Aminopiperidine-2,6-dione hydrochloride is the reagent used to prepare lenalidomide, which induces CK1α ubiquitination and degradation in del(5q) MDS. It can also be used to prepare phthalimide conjugates that promote ligand-dependent degradation of target proteins.

Application 3-Amino-2,6-piperidinedione hydrochloride is an important intermediate for lenalidomide Application 3-aminopiperidine-2,6-dione hydrochloride is a reagent for the preparation of lenalidomide , which induces CK1α ubiquitination and degradation in del(5q) MDS. It can also be used to prepare phthalimide conjugates that promote ligand-dependent degradation of target proteins. Synthesis A solution of 15 (4.00 g, 0.015 mol) in methanol (200 ml) and 2NHCl (15 ml) was hydrogenated with 5% Pd-C (100 mg) at 60 psi for 4 h. The catalyst was filtered off and the filtrate was concentrated to dryness to give the title compound 3-amino-2,6-piperidinedione hydrochloride (2.61 g, 100%) as a Chemicalbook white solid. mp245°C (dec) (lighting 235°C (dec)). 1HNMR (400MHz, DMSO-D6) δppm11.22 (brs, 1H), 8.68 (brs, 3H), 4.20 (dd, J=13.0, 5.3Hz, 1H), 2.77-2.65 (m, 1H), 2.64-2.56 (m, 1H), 2.27-2.19 (m, 3H) and 2.09-1.97 (m, 2H).