Raubasine
483-04-5
industrial Grade
98%
SHANGHAI
KieRay Chem
25kg/drum
2022-12-31
fine chemicals,pharmaceutical materials
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceAjmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1].Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2].Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3].Ajmalicine (Raubasine) acts preferentially at postsynaptic site
Vinca rosea L. yields this alkaloid which crystallizes as colourless needles from MeOH. The base is laevorotatory having a specific rotation of [α]D_620 (MeOH) and forms a crystalline hydrochloride, m.p. 281-3°e. The structure given above has been elucidated from chemical and spectroscopic data.
ChEBI: Ajmalicine is a monoterpenoid indole alkaloid with formula C21H24N2O3, isolated from several Rauvolfia and Catharanthus species. It is a selective alpha1-adrenoceptor antagonist used for the treatment of high blood pressure. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and a vasodilator agent. It is a monoterpenoid indole alkaloid, a methyl ester and an organic heteropentacyclic compound. It is a conjugate base of an ajmalicine(1+).
It crystallises from MeOH, EtOH or EtOAc. [Beilstein 27 III/IV 7927.]Basic Info-
Product Name:
Raubasine
Other Name:RAUBASIN;RAUBASINE;YOHIMBINE, C-;, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-;16,17-Didehydro-19alpha-methyloxayohimban-16-carboxylic acid methyl ester;16,17-Didehydro-19-methyloxayohimban-16-carboxylic acid methyl ester;16,17-didehydro-19-methyloxayohimban-16-carboxylicacidmethylester;19-Epiajmalicine
CAS No.:483-04-5
Molecular Formula:C21H24N2O3
InChIKeys:InChIKey=GRTOGORTSDXSFK-XJTZBENFSA-N
Molecular Weight:352.43
Exact Mass:352.43
BRN:97268
EC Number:207-589-5
NSC Number:95087|72133|72115
Color/Form:Pale Yellow
Categories:
Characteristics-
PSA:
54.6
XLogP3:2.88
Density:1.1823 (rough estimate)
Melting Point:258°C (rough estimate)
Boiling Point:486.04°C (rough estimate)
Flash Point:270.7±30.1 °C
Refractive Index:1.6500 (estimate)
Water Solubility:insoluble in water
Storage Conditions:2-8°C
Vapor Pressure:4.47E-11mmHg at 25°C
Toxicity:Peritoneal-rat LD50: 200 mg/kg; oral-mouse LD50: 400 mg/kg
Flammability characteristics:Combustible in case of open fire; toxic fumes of nitrogen oxides are emitted by mist burning
Specific rotation:D20 -60° (c = 0.5 in chloroform); D20 -45° (c = 0.5 in pyridine); D20 -39° (c = 0.25 in methanol)
PKA:pK1:10.55(+1) (25°C)
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
fine chemicals,pharmaceutical materials
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Location:
Room 260, Building 3, No. 76 Xingqiao North Road, Xingqiao Street, Yuhang District, Hangzhou City, Zhejiang Province, China
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2020
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
