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Ajmalicine

Ajmalicine structure

CAS No:
483-04-5
Formula:
C21H24N2O3
Chemical Name:
Ajmalicine
Synonyms:
Oxayohimban-16-carboxylic acid,16,17-didehydro-19-methyl-,methyl ester,(19α)-;Raubasine;Ajmalicine;4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine,oxayohimban-16-carboxylic acid deriv.;Hydrosarpan;Py-tetrahydroserpentine;δ-Yohimbine;Lamuran;Tetrahydroserpentine;Ajmalicin;Raubasin;Vincain;Vincein;Vinceine;Raumalina;Rauvasan;Sarpan;Tensyl;Ranitol;Raubaserp;Raubasil;(-)-Ajmalicine;Vincaine;4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid,4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-,methyl ester,(4S,4aR,13bS,14aS)-;Circolene;Isoarteril;NSC 72133;NSC 95087;478483-39-5
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1].Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2].Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3].Ajmalicine (Raubasine) acts preferentially at postsynaptic site

Ajmalicine Basic Attributes

Molecular Weight：

352.43

Exact Mass：

352.43

EC Number：

207-589-5

NSC Number：

95087|72133|72115

Characteristics

PSA：

54.6

XLogP3：

2.88

Density：

1.3±0.1 g/cm3

Melting Point：

258 °C (decomp)

Boiling Point：

524.0±50.0 °C at 760 mmHg

Flash Point：

270.7±30.1 °C

Refractive Index：

1.656

Storage Conditions：

2-8°C

Vapor Pressure：

4.47E-11mmHg at 25°C

Toxicity：

Peritoneal-rat LD50: 200 mg/kg; oral-mouse LD50: 400 mg/kg

Flammability characteristics：

Combustible in case of open fire; toxic fumes of nitrogen oxides are emitted by mist burning

Specific rotation：

D20 -60° (c = 0.5 in chloroform); D20 -45° (c = 0.5 in pyridine); D20 -39° (c = 0.25 in methanol)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

wgk germany：

hazard class code：

25-22

safety instructions：

22-45

RTECS Number：

AX7875000

Marks：

Storage features：

The warehouse is ventilated at low temperature and dry; stored separately from oxidants, acids and food additives

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

19-epiajmalicine

Ajmalicine Use and Manufacturing

Antihypertensive, anti-ischemic (cerebral and peripheral)

Computed Properties

Molecular Weight:352.4
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:352.17869263
Monoisotopic Mass:352.17869263
Topological Polar Surface Area:54.6
Heavy Atom Count:26
Complexity:606
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

A vasodilator with alpha-antiadrenergic activity related to postsynaptic alpha-blocker action

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Amitrine Luobaxin Tablets
Ingredients	Each tablet contains 30 mg of amitriptyline and 10 mg of raubasin
Specifications	10mg*30 tablets/box

Amitrine Mesylate Luobaxin Tablets
Ingredients	Each tablet: 30 mg of almitrine, 10 mg of raubasin. Chemical name: Molecular formula: Molecular weight:
Indication	drugInteractions
Specifications	30mg/10mg*30s

Amitrine Mesylate Luobaxin Tablets
Ingredients	Each tablet: 30 mg of almitrine, 10 mg of raubasin. Chemical name: Molecular formula: Molecular weight:
Indication	drugInteractions
Specifications	Almitrine mesylate 30 mg, Raubasin 10 mg/tablet

See More Related Drugs

Registered Holders

Henan Life Pharmaceutical Co., Ltd.

China
Active

Recommended Suppliers of Ajmalicine

Hangzhou KieRay Chem Co.,LTD Contact Supplier

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Raubasine

CAS No.: 483-04-5

Grade: industrial Grade

Content: 98%

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Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

Raubasine

CAS No.: 483-04-5

Grade: Industrial Grade

Content: 99%

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