Hair loss treatment Setipiprant, SETIPIPRANT 99% white powder 866460-33-5 Senwayer

Setipipran is an oral drug that’s currently being tested for use as a hair loss treatment. It was initially developed as a treatment for allergic rhinitis, but recent hair loss-related discoveries have made it a better candidate for hair loss reversal.

For Allergies/Asthma

As setipiprant is believed to interfere with the receptors known to contribute to allergies/allergic responses, the drug was first tested on allergies and asthma.

In clinical trials, the drug performed quite well in the treatment of allergen-induced airway responses in asthmatic patients. It was also well tolerated by participants. However, its results were similar to those of drugs already on the market, so further trials were discontinued.

For Hair Loss

In 2012, researchers discovered a link between the PGD2 receptor and hair loss. More specifically, this receptor is seen at high levels in the scalps of men diagnosed with Androgenetic Alopecia (AGA).

AGA (Male-Pattern Baldness) is the most common cause of hair loss in men, though it’s also seen in women (Female Pattern Hair Loss). It’s believed to be caused by a sensitivity to DHT, which is an androgen hormone that attaches to the follicles and leads to inflammation and irritation.

There’s no doubt that setipiprant and finasteride have a similar end game, and that’s to prevent hair loss. But how different are their mechanisms, and which is better?

If you think of the hair loss process as a timeline, then finasteride interferes much sooner in the process. That is, it inhibits the expression of 5-alpha-reductase (5AR), which is responsible for the production of DHT. In this way, less androgen receptors are activated on the scalp and PGD2 production is slowed or even ceased.

Setipiprant, though, enables 5AR to create DHT, and the process continues until PGD2 comes into play. It is then that the drug interferes, preventing PGD2 receptors from being activating (which is, essentially, the final step).

While the full effects of setipiprant on hair loss are still unknown, previous studies have shed some light on possible adverse effects.

The studies which were focused on setipiprant as a treatment for allergic rhinitis and asthma saw side effects, such as:

• Dry mouth
• Nausea
• Drowsiness
• Elevation of liver enzymes
• 
• Anxiety

In one patient, cholelithiasis (gallstones) developed during the time of the trial. This could very well be directly related to setipiprant (as it’s been shown to effect liver enzymes).

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