Pharmaceutical Material Phenolphthalein Powder CAS 77-09-8 API Phenolphthalein
GMP ISO 1 Inquiries
77-09-8
Pharmaceutical Grade
99%
XAZB
Boil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Inquiry History
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Description
Brand XAZB Product Name Phenolphthalein CAS No. 77-09-8 EINECS 201-004-7 Molecular Formula C20H14O4 Molecular Weight 318.32276 Appearance White to light yelow powder Purity 99%
COA of PhenolphthaleinTEST ITEM
SPECIFICATION
RESULTS
Characteristics
A white or almost white powder, practically insoluble in water, soluble in alcohol.
A white powder, practically insoluble in water, soluble in alcohol.
Melting Point
It melts at about 260°C.
261ºC.~262ºC.
Identification
A: Positive
B: Positive
A: Positive
B: Positive
Appearance of solution
The solution is clear and not more intensely colored than reference solution Y7
Complies
Related substances
Less than 0.5%
<0.5%
Heavy metals
Not more than0.001%
<0.001%
Acidity or alkalinity
Complies
Complies
Chlorides
Not more than 0.01%
<0.01%
Sulfates
Not more than 0.02%
<0.02%
Loss on drying
Not more than 0.5%
0.12%
Sulfated ash
Not more than 0.1%
0.01%
Assay
98.0%-101.0%(C20H14O4)
99.6%
CONCLUSION: Conform With EP6/BP2009
Classification
Digestive system drugs> Promote diarrhea drugsPharmacological effects
Phenolphthalein irritating laxatives, the main role in the large intestine. After oral administration in the intestinal alkaline environment to form soluble sodium salt, stimulate the plexus wall plexus, a direct role in the intestinal smooth muscle, so that peristalsis increased.
At the same time phenolphthalein and inhibit intestinal absorption of water, so that water and electrolyte accumulation in the colon,
resulting in laxation effect. The role of strength and intestinal size of alkaline, and its role in mild, rarely cause intestinal spasm.Pharmacokinetics
Phenolphthalein after oral 6 ~ 8h effect. About 15% of oral absorption after absorption of drugs mainly in the form of glucuronide by the kidneys or excretion of excreted, some can also be excreted to the intestine by the bile, was reabsorbed in the intestine to form enterohepatic circulation, thereby prolonging the duration of action, So the role of a single administration of sustainable 3 to 4 days. The unabsorbed part is excreted via feces. Phenolphthalein can also be secreted by milk.Indications
1 for habitual intractable constipation.
2. In the colon, rectal endoscopy or X-ray examination for cleaning the intestine.Contraindications
1. Allergic to phenolphthalein.
2. Baby
3. Appendicitis
4. Rectal bleeding is not diagnosed.
5. Congestive heart failure.
6. Hypertension.
7. Intestinal obstruction.
8. Renal insufficiency.
9. fecal blockage.Precautions
1. Young children and pregnant women with caution.
2. Should be taken before going to bed, to avoid abuse of phenolphthalein.Adverse reactions
Phenolphthalein is a widely accepted laxative that is readily accepted by patients. Occasionally intestinal cramps, bleeding tendency,
a rare allergic reaction. Overdose or long-term drug disorders, induced arrhythmia, confusion, muscle spasms, and fatigue, and other symptoms.Dosage
Each 50 ~ 200mg, Dayton clothing before going to bed. Bedridden each time 200mg. The amount of each 500mg, 1g daily. Increase
or decrease according to the patient's condition.Medicine interactions
Phenolphthalein and sodium bicarbonate, magnesium oxide, and other alkaline drugs can cause discoloration of urine.Poisoning
Phenolphthalein (Fenofutin; fruit guide for the drug-containing tablets) as a laxative agent, due to the small amount of absorption after the results of enterohepatic circulation, the role of sustainable 3 ~ 4d. Commonly used before going to bed 0.05 ~ 0.2g. When poisoning mainly
damage the liver and kidneys.
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CertificatesBasic Info-
Product Name:
3,3-Bis(4-hydroxyphenyl)phthalide
Other Name:1(3H)-Isobenzofuranone,3,3-bis(4-hydroxyphenyl)-;Phenolphthalein;3,3-Bis(4-hydroxyphenyl)-1(3H)-isobenzofuranone;3,3-Bis(4-hydroxyphenyl)phthalide;Purga;Laxogen;Spulmako-lax;Lilo;Trilax;Koprol;Purgophen;Euchessina;Phthalimetten;Purgen;Phthalin;3,3-Bis(p-hydroxyphenyl)phthalide;NSC 10464;NSC 215214;TY 9;PX 0520-1;3,3-Bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one;3,3-Bis(4-hydroxyphenyl)-2-benzofuran-1-one;467-29-8;57214-20-7;390417-24-0;546094-13-7;1541170-18-6
CAS No.:77-09-8
Molecular Formula:C20H14O4
InChIKeys:InChIKey=KJFMBFZCATUALV-UHFFFAOYSA-N
Molecular Weight:318.32
Exact Mass:318.32
BRN:284423
EC Number:201-004-7
UNII:6QK969R2IF
NSC Number:757271|215214|10464
UN Number:1993
DSSTox ID:DTXSID0021125
NCI Thesaurus Code:C29359
Color/Form:White or yellowish-white minute, triclinic crystals, often twinned|White rhombic needles|Pale yellow powder
ATC Code:A - Alimentary tract and metabolism
HScode:29322910
Categories:
Characteristics-
PSA:
66.8
XLogP3:3.6
Appearance:White to yellow-white Solid
Density:1.277 g/cm3 @ Temp: 32 °C
Melting Point:262.5 °C
Boiling Point:557.8±50.0 °C at 760 mmHg
Flash Point:24 °C
Refractive Index:1.693
Water Solubility:H2O: <0.1 g/100 mL;soluble in alcohol. Slightly soluble in ether. Slightly soluble in dimethyl sulfoxide and insoluble in benzene or hexane.
Storage Conditions:Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.
Vapor Pressure:6.7X10-13 mm Hg @ 25 deg C /Estimated/
Odor:ODORLESS
PKA:9.7(at 25 °C)
Henrys Law Constant:Henry's Law constant = 9.0X10-16 atm-cu m/mol @ 25 °C /Estimated/
Dissociation Constants:9.7 (at 25 °C)|pKa = 9.7 at 25 °C
Collision Cross Section:172.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Solutions are colorless to pH 8.5; pink to deep-red, above pH 9|Forms an almost colorless solution in neutral or acid solution, pink to deep red in presence of alkali, but colorless in the presence of large amounts of alkali.|Hydroxyl radical reaction rate constant = 8.4X10-11 cu cm/molecule-sec @ 25 °C /Estimated/
Air and Water Reactions:Insoluble in water.
Reactive Group:Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Reactivity Profile:PHENOLPHTHALEIN is incompatible with alkaloids. (NTP, 1992)
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H341 Suspected of causing genetic defects
H350 May cause cancer
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
Phenolphthalein
25.00 KG Oct 12, 2025 Post an enquiry for this product
