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Pharmaceutical Intermediates Deferasirox for Hemochromatosis CAS 201530-41-8

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CAS No.:

201530-41-8

Grade:

Pharmaceutical Grade

Content:

99%

Packaging:

Foil Bag, Box, Drum

Sample Available:

Yes

Price valid (until):

2022-12-31

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Xian ZB Biotech Co.,Ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents

Average Lead Time:

8 days

Qualification:

Main Products:

Herb Extracts,Cosmetic raw materails,API

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Product Description
Seller Information
Inquiry History

Description

Product Description

_{Product Name: Deferasirox
Synonyms: 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid;deferasirox;Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-;Deferasirox for research;4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic Acid;CGP-72670;Exjade;ICL-670
CAS: 201530-41-8
MF: C21H15N3O4
MW: 373.3615
Product Categories: Chelating agent (iron);Aromatics Compounds;Aromatics;Chelating Agents & Ligands;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate;Exjade, ICL-670, ICL-670A, CGP-72670
Melting point 260-262ºC
Storage temp. -20°C Freezer
Chemical Properties White to Off-White Solid
Usage Orally active tridentate iron chelator
Usage Biological Activity Chemical Information Tech Support & FAQs Biological Activity Deferasirox(Exjade) is a rationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions
Usage A tridentate chelator that binds iron with high affinity .
Usage Labeled Deferasirox, intended for use as an internal standard for the quantification of Deferasirox by GC- or LC-mass spectrometry.

Deferasirox: chemical name 4- [3,5-bis (2-hydroxyphenyl) -1,2,4-triazol-1-yl] benzoic acid, is a kind of iron chelator products studied and developed by the Novartis company (Swiss). It was the first routinely used oral iron agent approved by US FDA, allowed to be applied for the treatment of iron overloading caused by blood transfusion in patients (older than 2 years old) of chronic anemia. In Europe, it is recommended as the first-line treatment drug for patients older than 6-year-old who are suffering blood iron overload patients.
In China, it is currently subject to clinical research; 2, 3 clinical trials and pharmacokinetic studies have all shown that it has excellent safety and tolerability, and can significantly reduce the heart, liver iron load, easy to be accepted by the patient. At the same time, it also has pharmacological properties of antifungal (such as Mucor which can grow in iron-ricking environment), anti-cell proliferation, anti-malaria, antioxidant stress injury and anti-cytotoxicity induced apoptosis; it can be used for the treatment of hemochromatosis, delayed skin porphyria and other diseases.}

Application

_{1. DFS can be used to treat the reversible renal insufficiency caused by Fanconi syndrome.
2. It can be used for the treatment of secondary hemochromatosis.
3. It can be used for the treatment of delayed skin porphyria.
4. It can be used for the treatment of myelodysplastic syndromes.
5. It can be used for the treatment of iron overloading caused by blood transfusion for patients (older than 2 years old) of chronic anemia .}

Product Photo

ECHEMI Editorial Reference

Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.
Solid
Deferasirox is a member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions. It has a role as an iron chelator. It is a member of triazoles, a monocarboxylic acid, a member of benzoic acids and a member of phenols. It derives from a 2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol.|Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.|Deferasirox is an Iron Chelator. The mechanism of action of deferasirox is as an Iron Chelating Activity, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 2C8 Inhibitor, and Cytochrome P450 1A2 Inhibitor.|Deferasirox is an oral iron chelating agent used to treat chronic iron overload. Deferasirox has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury, which can be severe and even fatal.|Deferasirox is a synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.|A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.

Research & Reference Note

Pharmaceutical Intermediates Deferasirox for Hemochromatosis CAS 201530-41-8 is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Authoritative sources

Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

Certificates

Basic Info

Product Name:

Deferasirox

Other Name:

Benzoic acid,4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-;4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid;ICL 670A;ICL 670;Deferasirox;4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid;Exjade;Asunra;Jadenu

CAS No.:

201530-41-8

Molecular Formula:

C21H15N3O4

InChIKeys:

InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N

Molecular Weight:

373.3615

Exact Mass:

373.36

EC Number:

1806241-263-5

UNII:

V8G4MOF2V9

DSSTox ID:

DTXSID1048596

NCI Thesaurus Code:

C48384

Color/Form:

Crystals from ethanol|White to slightly yellow powder

ATC Code:

V03AC03|V - Various

HScode:

2933990090

Categories:

Blood System Drugs

Characteristics

PSA:

109 Å²

XLogP3:

log Kow = 6.30 (pH 7.4)|3.52

Density:

1.4±0.1 g/cm3

Melting Point:

260-2620C

Boiling Point:

651°C at 760 mmHg

Flash Point:

360.3±34.3 °C

Refractive Index:

1.699

Water Solubility:

In water, 0.4 mg/mL at 25 °C (pH 7.40)|3.43e-02 g/L

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.67X10-13 mm Hg at 25 °C (est)

Henrys Law Constant:

Henry's Law constant = 1.4X10-17 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 4.57; pKa2 = 8.71; pKa3 = 10.56|Dissociation constant also reported in H2O/DMSO (X(DMSO = 0.20) as pKa1 = 4.61; pKa2 = 10.12; pKa3 = 12.08

Experimental Properties:

Hydroxyl radical reaction rate constant = 2.05X10-10 cu cm/molec-sec at 25 °C (est)

See More Deferasirox Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Deferasirox Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Herb Extracts,Cosmetic raw materails,API

Location:
1403,Jinye B Block

Payment Terms:
TT against copy of documents

Average lead Time:
8 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2015

Xian ZB Biotech Co.,Ltd is a leading Manufactory supplier of Arbutin, Nicotinamide, Flucytosine based in Xi'an, Shaanxi, China. With a commitment to quality and customer satisfaction, Xian ZB Biotech Co.,Ltd has become a trusted name in the industry. Our product line includes a range of high-quality Arbutin, Nicotinamide, Flucytosine, which are available at competitive prices. Xian ZB Biotech Co.,Ltd has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Deferasirox	25 KG	Mar 19, 2024
Hongkong, China	Deferasirox is an iron chelator (binder)	5000 KG	May 12, 2025

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Pharmaceutical Intermediates Deferasirox for Hemochromatosis CAS 201530-41-8

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